4'-Chloropropiophenone, a compound with the CAS number 6285-05-8, stands as a cornerstone in the realm of organic synthesis. Its versatility as an intermediate makes it highly sought after in various industries, particularly pharmaceuticals and specialty chemicals. Understanding its synthesis is crucial for appreciating its value and for sourcing it reliably.

One of the primary methods for synthesizing 4'-Chloropropiophenone involves the Friedel-Crafts acylation reaction. This classic organic chemistry reaction typically utilizes chlorobenzene as the aromatic substrate and propionyl chloride or propionic anhydride as the acylating agent, in the presence of a Lewis acid catalyst such as aluminum chloride (AlCl3). The reaction proceeds by electrophilic aromatic substitution, where the propionyl group attaches to the para position of the chlorobenzene ring, yielding 4'-Chloropropiophenone. The purity of the starting materials and precise control over reaction conditions, including temperature and catalyst concentration, are paramount to achieving high yields and purity.

Another significant synthetic approach, often favored for its efficiency and specific outcomes, can involve the reaction of p-chlorobenzenesulfonyl chloride with chloroacetone. While the specifics of this method are more technical, it highlights alternative routes available to chemical manufacturers. At NINGBO INNO PHARMCHEM CO.,LTD., we are dedicated to optimizing these synthesis processes to ensure the production of high-quality 4'-Chloropropiophenone. Our commitment to rigorous quality control means that every batch meets stringent purity standards, often exceeding 99%.

The demand for this compound is driven by its extensive use. For instance, its role as a pharmaceutical intermediate is well-documented, serving as a precursor in the synthesis of various active pharmaceutical ingredients (APIs). Researchers looking to buy 4'-Chloropropiophenone for drug development projects often seek suppliers who can guarantee consistent quality and reliable supply. Similarly, the fragrance and polymer industries utilize this organic intermediate for its unique properties.

When considering the purchase of 4'-Chloropropiophenone, factors such as purity, price, and supplier reliability are key. NINGBO INNO PHARMCHEM CO.,LTD. offers competitive pricing for 4'-Chloropropiophenone, ensuring that businesses can access this essential chemical without compromising their budget. Our efficient manufacturing and supply chain management allow us to provide competitive prices for bulk purchases, making us a preferred supplier for many clients.

In conclusion, the synthesis of 4'-Chloropropiophenone is a well-established process, with Friedel-Crafts acylation being a prominent method. At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to excellence in both production and supply, ensuring that our clients receive the highest quality 4'-Chloropropiophenone for their diverse applications. For those seeking to purchase this vital chemical, our company offers a reliable source with excellent price points.