Exploring the Synthesis Pathways Involving Methyl 11-Bromoundecanoate
NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting scientific advancement by providing essential chemical intermediates like Methyl 11-Bromoundecanoate (CAS: 6287-90-7). This compound, with its versatile functional groups, plays a key role in numerous sophisticated synthesis pathways.
A prominent application for Methyl 11-Bromoundecanoate involves its transformation into intermediates for the synthesis of acetylenic cyclophanes. The terminal bromine atom is readily displaced by nucleophiles, or it can be involved in coupling reactions, paving the way for ring formation critical in creating these macrocyclic structures. This makes it an indispensable starting material for researchers exploring novel conjugated systems and advanced materials. The purchase of this compound is a strategic move for laboratories focused on cutting-edge material science.
In the realm of medicinal chemistry, Methyl 11-Bromoundecanoate is frequently utilized in the construction of complex side chains for biologically relevant molecules. For instance, its application in synthesizing the side chain for emmyguyacins showcases how its long alkyl chain and reactive bromide can be strategically employed to build intricate molecular architectures. These pathways often involve multi-step functional group transformations, where the purity of the initial Methyl 11-Bromoundecanoate is paramount for achieving high yields and the desired stereochemistry.
Furthermore, Methyl 11-Bromoundecanoate is a foundational component in the development of PROTAC linkers. The synthesis of these linkers often requires the coupling of various molecular fragments. The alkyl bromide end of Methyl 11-Bromoundecanoate can be readily functionalized, for example, via reactions with thiols or amines, to extend the linker chain and attach other functional moieties. This adaptability makes it a cornerstone for researchers working on targeted protein degradation therapies. Ensuring a reliable supply chain for this intermediate is crucial for the continuous progress in these advanced synthetic endeavors.
Perspectives & Insights
Nano Explorer 01
“These pathways often involve multi-step functional group transformations, where the purity of the initial Methyl 11-Bromoundecanoate is paramount for achieving high yields and the desired stereochemistry.”
Data Catalyst One
“Furthermore, Methyl 11-Bromoundecanoate is a foundational component in the development of PROTAC linkers.”
Chem Thinker Labs
“The synthesis of these linkers often requires the coupling of various molecular fragments.”