At NINGBO INNO PHARMCHEM CO.,LTD., we believe that a thorough understanding of chemical properties is the foundation for successful scientific endeavors. Today, we delve into the characteristics of 4-chloro-3-iodobenzotrifluoride (CAS 672-57-1), a compound of significant interest in various fields of chemistry. Its unique combination of functional groups makes it a valuable asset for synthetic chemists.

Physically, 4-chloro-3-iodobenzotrifluoride is typically described as a yellow liquid. Its molecular formula is C7H3ClF3I, with a molecular weight of approximately 306.45 g/mol. The density is reported to be around 1.973 g/cm³, indicating a relatively heavy compound, which is not unusual for molecules containing iodine. Its boiling point under reduced pressure (0.5 mmHg) is noted as 58-60 °C, suggesting it can be purified via distillation. Understanding these physical attributes is crucial for handling, storage, and reaction design, especially when looking to purchase this intermediate.

Chemically, the significance of 4-chloro-3-iodobenzotrifluoride lies in its trifunctionalized benzene ring. The trifluoromethyl (CF3) group is a strong electron-withdrawing substituent, influencing the reactivity of the aromatic ring and imparting lipophilic properties. The iodine atom is an excellent leaving group, readily participating in palladium-catalyzed cross-coupling reactions like Suzuki, Stille, and Sonogashira couplings, making it a prime choice for organic synthesis building blocks. The chlorine atom also offers potential for nucleophilic aromatic substitution or other transformations, though it is generally less reactive than iodine in coupling reactions.

This versatility makes it an indispensable pharmaceutical intermediate. The ability to precisely introduce functional groups via the halogen handles allows for the construction of complex drug candidates with tailored pharmacological profiles. Researchers often seek to buy these halogenated aromatic compounds for their role in creating new chemical entities with improved efficacy and stability. The importance of iodinated organic compounds in modern synthetic chemistry cannot be overstated.

NINGBO INNO PHARMCHEM CO.,LTD. supplies 4-chloro-3-iodobenzotrifluoride at high purity levels, typically 97-98%, ensuring that the CAS 672-57-1 chemical properties are consistent and reliable for research applications. Whether used in the synthesis of new pharmaceuticals, advanced materials, or in academic research exploring novel reaction pathways involving specialty fluorinated chemicals, this compound offers immense potential. Its well-defined chemical structure and reactivity make it a cornerstone for many innovative projects.