Ethyl 3-aminocrotonate, identified by CAS number 626-34-6, is a compound of significant interest in the chemical industry due to its versatile applications, particularly as a synthetic intermediate. Understanding its chemical properties and synthesis is crucial for its effective utilization and safe handling. This article provides a detailed exploration of these aspects.

The chemical structure of Ethyl 3-aminocrotonate features an ester group and an amine group conjugated with a double bond, making it an enamine ester. This unique arrangement confers distinct reactivity. Its physical properties include a melting point typically ranging from 33-35°C, and it is known to be soluble in water to an extent of 26 g/L at 25°C. A notable characteristic is its sensitivity to air and moisture, and it is also hygroscopic, meaning it readily absorbs moisture from the atmosphere. These properties necessitate storage in well-sealed containers, often under an inert atmosphere, and in a cool, dry place to maintain its integrity. Several sources also list a boiling point around 210-215°C.

The synthesis of Ethyl 3-aminocrotonate commonly involves the reaction between ethyl acetoacetate and ammonia. This reaction is a straightforward condensation process that can be efficiently carried out under controlled conditions. For instance, using a continuous flow reactor with ethyl acetoacetate and a 25% aqueous ammonia solution in a specific ratio and residence time has yielded high product yields at moderate temperatures. This emphasis on efficient Ethyl 3-aminocrotonate synthesis ensures its availability for various industrial applications.

The compound's classification as a fine chemical intermediate means it serves as a building block for more complex molecules. Its applications span across organic synthesis, where it's used to create a variety of organic compounds, and importantly, as a pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs). Additionally, it finds utility as a feed auxiliary agent, contributing to animal nutrition. The ability to reliably buy Ethyl 3-aminocrotonate online from reputable Ethyl 3-aminocrotonate suppliers facilitates its widespread use.

Safety considerations are paramount when working with Ethyl 3-aminocrotonate. Its hazard codes often include classifications for corrosivity and potential respiratory irritation. Therefore, appropriate personal protective equipment (PPE), such as gloves, eye protection, and respiratory masks, should be used when handling it. Thorough understanding of the Ethyl 3-aminocrotonate properties and adhering to safe handling practices, as outlined by suppliers and safety data sheets (SDS), are essential for minimizing risks. Knowledge of the diverse Ethyl 3-aminocrotonate uses is also vital for optimizing its application.