Understanding the fundamental properties and synthesis routes of chemical intermediates is crucial for their effective application in research and industry. Pyrimidine-5-carboxaldehyde (CAS 10070-92-5) is a prime example of such a compound, serving as a valuable building block in numerous chemical processes. This article delves into the key chemical properties and common synthesis methods for this important fine chemical.

Pyrimidine-5-carboxaldehyde is characterized by its molecular formula C5H4N2O and a molecular weight of approximately 108.10 g/mol. Physically, it typically presents as a light yellow to yellow solid. Its melting point is generally reported in the range of 39-43°C, indicating a relatively low melting solid at room temperature. The boiling point is recorded as 80-82°C at a pressure of 4 mmHg, suggesting it can be distilled under reduced pressure without significant decomposition. These physical attributes are important for its handling, purification, and use in various reaction conditions.

The synthesis of Pyrimidine-5-carboxaldehyde often involves multi-step organic reactions. A common approach described in literature includes the lithiation of a pyrimidine precursor, such as 5-bromopyrimidine, at very low temperatures (e.g., -78°C) using reagents like n-butyllithium. This is followed by the addition of an electrophile, such as ethyl formate, to introduce the aldehyde group. The reaction mixture is then quenched and purified, often through techniques like column chromatography, to isolate the desired product. The overall yield and purity depend heavily on precise control of reaction parameters, including temperature, solvent, and reactant addition rates. Sourcing high-quality starting materials and carefully following established protocols are key to successful Pyrimidine-5-carboxaldehyde synthesis.

For researchers and manufacturers seeking to buy Pyrimidine-5-carboxaldehyde, understanding these synthesis details can inform procurement decisions. High purity, typically specified as 98% or higher, is often a requirement for downstream applications in pharmaceuticals and agrochemicals. Reliable Pyrimidine-5-carboxaldehyde suppliers are those who can consistently deliver material meeting these stringent specifications. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing Pyrimidine-5-carboxaldehyde with guaranteed purity, enabling efficient and reproducible results for our clients.

The stability and storage of Pyrimidine-5-carboxaldehyde are also important considerations. While it is generally stable under recommended storage conditions (cool, dry, and tightly closed), specific handling instructions, often found in Material Safety Data Sheets (MSDS), should always be followed. Awareness of its chemical reactivity, such as potential incompatibility with strong oxidizing agents, is vital for safe laboratory practices.

In conclusion, Pyrimidine-5-carboxaldehyde is a valuable intermediate whose utility is amplified by a thorough understanding of its chemical properties and synthesis. By providing access to this key compound, NINGBO INNO PHARMCHEM CO.,LTD. supports the scientific community in its diverse applications, from drug discovery to agricultural innovation.