The field of medicinal chemistry continuously seeks novel compounds with therapeutic potential. Nicotinamide derivatives, owing to their structural similarity to Vitamin B3 and their involvement in various biological pathways, are of particular interest. N-(2-hydroxyethyl)isonicotinamide (CAS 6265-74-3) stands out among these derivatives due to its unique pharmacological profile and utility as an organic synthesis intermediate. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality compounds like N-(2-hydroxyethyl)isonicotinamide to support critical research in this domain.

While structurally related to well-known compounds such as Nicorandil, N-(2-hydroxyethyl)isonicotinamide exhibits distinct biological activities. Unlike Nicorandil, which acts as a dual-action vasodilator by activating ATP-sensitive potassium channels and soluble guanylyl cyclase through nitric oxide donation, N-(2-hydroxyethyl)isonicotinamide does not significantly modulate these pathways. This difference is attributed to the absence of the nitrate moiety in its structure, which is crucial for nitric oxide release and subsequent activation of guanylyl cyclase. Research indicates that N-(2-hydroxyethyl)isonicotinamide requires much higher concentrations to elicit any vasodilation, and it does not influence cyclic guanosine monophosphate levels, a key second messenger in vasodilation. Understanding these distinctions is vital for researchers looking to buy N-(2-hydroxyethyl)isonicotinamide for specific pharmacological investigations.

The pharmacological investigations into N-(2-hydroxyethyl)isonicotinamide also extend to its potential as an antinociceptive agent and its influence on metabolic pathways. While not a direct nitric oxide donor, it may interact with other cellular signaling cascades. Furthermore, its role as a precursor in nicotinamide adenine dinucleotide (NAD+) biosynthesis pathways means it can contribute to cellular energy homeostasis and redox balance. The metabolites derived from N-(2-hydroxyethyl)isonicotinamide can participate in paracrine signaling, influencing various cellular functions. NINGBO INNO PHARMCHEM CO.,LTD. supplies this compound for studies exploring these complex biological interactions.

The positional isomerism of nicotinamide derivatives also plays a significant role in their pharmacological efficacy. Studies comparing meta-, ortho-, and para-substituted isomers of Nicorandil analogs have shown that the meta-position often correlates with enhanced activity, particularly in terms of antinociceptive effects and nitric oxide release. While N-(2-hydroxyethyl)isonicotinamide itself does not directly release nitric oxide in the same manner as its nitrated counterparts, understanding these structure-activity relationships helps researchers predict and design new nicotinamide derivatives with desired properties. NINGBO INNO PHARMCHEM CO.,LTD. offers high-quality N-(2-hydroxyethyl)isonicotinamide that serves as a valuable reference compound in such comparative studies.

In summary, N-(2-hydroxyethyl)isonicotinamide is a valuable compound with a unique pharmacological profile compared to its related nicotinamide derivatives. Its utility as an organic synthesis intermediate and its potential for distinct biological activities make it a subject of ongoing research. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting scientific exploration by providing this compound with guaranteed high purity, at competitive prices, ensuring that researchers have access to reliable materials for their groundbreaking work. When you need to purchase N-(2-hydroxyethyl)isonicotinamide, NINGBO INNO PHARMCHEM CO.,LTD. is your trusted supplier.