In the intricate field of medicinal chemistry, understanding how a molecule's structure dictates its biological activity is fundamental to drug discovery and development. N-(2-hydroxyethyl)isonicotinamide (CAS 6265-74-3) offers a fascinating case study when compared with its closely related analogs, particularly Nicorandil. NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality N-(2-hydroxyethyl)isonicotinamide to facilitate research into these critical structure-activity relationships (SAR).

A key distinction lies in the pharmacological mechanisms. Nicorandil, a drug used for angina, exhibits dual-action vasodilation through two main pathways: opening ATP-sensitive potassium (KATP) channels and activating soluble guanylyl cyclase (sGC) via nitric oxide (NO) release. The latter function is critically dependent on the nitrate ester group present in Nicorandil. N-(2-hydroxyethyl)isonicotinamide, lacking this nitrate moiety, does not effectively release nitric oxide and therefore does not activate sGC or significantly modulate KATP channels. This structural difference leads to a fundamentally different biological profile. While researchers may seek to buy N-(2-hydroxyethyl)isonicotinamide for its own unique properties, it is crucial to recognize it does not replicate Nicorandil's primary therapeutic mechanisms.

The importance of specific functional groups and their positional arrangement is evident when examining related compounds. For instance, the position of the carboxamide group on the pyridine ring in nicotinamide derivatives can influence their pharmacological activity, including their potential for NO release and antinociceptive effects. Studies on Nicorandil analogs have shown that meta-substituted isomers often exhibit superior activity compared to ortho- or para-substituted ones. N-(2-hydroxyethyl)isonicotinamide, with its isonicotinamide structure (where the amide is at the 4-position of the pyridine ring, unlike Nicorandil's nicotinamide at the 3-position), possesses a distinct spatial arrangement that influences its interactions with biological targets.

Furthermore, N-(2-hydroxyethyl)isonicotinamide's role as a precursor in NAD+ biosynthesis pathways offers another dimension to its SAR. Its conversion into various metabolites can lead to paracrine signaling effects within cells, influencing metabolic processes and cellular signaling cascades. Understanding these metabolic fates and the resulting bioactive molecules is essential for fully appreciating the compound's biological footprint. NINGBO INNO PHARMCHEM CO.,LTD. supplies this intermediate for researchers investigating these complex biological interactions and metabolic pathways.

In conclusion, the comparison between N-(2-hydroxyethyl)isonicotinamide and compounds like Nicorandil highlights the profound impact of subtle structural variations on pharmacological activity. The absence of the nitrate group and the positional difference in the amide linkage result in distinct mechanisms of action. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-quality N-(2-hydroxyethyl)isonicotinamide to support scientific inquiry into these crucial structure-activity relationships. By purchasing this compound from us, researchers gain access to a reliable source for exploring the nuanced chemistry and biology of nicotinamide derivatives.