The landscape of organic synthesis is continuously shaped by the availability of effective and versatile chemical intermediates. 1,3-Dimethyl-5-iodobenzene, identified by its CAS number 22445-41-6, is one such compound that plays a significant role in building complex molecular structures. Its structure, featuring an iodine atom on a dimethyl-substituted benzene ring, makes it a particularly useful reagent for a variety of chemical transformations.

The Chemical Identity of 1,3-Dimethyl-5-iodobenzene

This compound, also known as 1-Iodo-3,5-dimethylbenzene, is classified as an organic synthesis intermediate. Its physical appearance is described as a pink-brown to red transparent liquid, with a specified purity of ≥98.0%. Key physical properties include a density of 1.6±0.1 g/cm³ and a boiling point of 229.9±9.0 °C at 760 mmHg. The refractive index is 1.593. These characteristics are crucial for its identification and for ensuring successful implementation in synthesis protocols. The compound is typically supplied in 200 kg drums and should be stored in a cool, ventilated environment.

Synthetic Utility and Reactions

The iodine atom in 1,3-dimethyl-5-iodobenzene is a prime functional group for various synthetic methodologies. It readily participates in palladium-catalyzed cross-coupling reactions, such as Suzuki, Heck, and Sonogashira couplings, which are vital for constructing new carbon-carbon bonds. These reactions are foundational in the synthesis of pharmaceuticals, agrochemicals, and materials with specific electronic or optical properties. The methyl substituents can also influence the reactivity and selectivity of these transformations.

Procurement and Quality Assurance

For chemists engaged in research and development, securing a reliable supply of high-quality 1,3-dimethyl-5-iodobenzene is essential. When considering where to buy this compound, it is important to choose suppliers that guarantee purity levels of ≥98.0%. Partnering with reputable manufacturers ensures consistency and reliability, which are critical for reproducible experimental results. Investigating various prices and availability from different sources can help optimize procurement strategies for both small-scale research and larger production needs.

The Importance of Intermediates in Chemical Innovation

The consistent availability of intermediates like 1,3-dimethyl-5-iodobenzene underpins innovation in chemical sciences. By providing a ready source of functionalized aromatic rings, it allows chemists to focus on designing and executing complex synthetic routes. Its role in the efficient synthesis of target molecules underscores the importance of a robust supply chain for fine chemicals. Whether for academic research or industrial applications, understanding the properties and sourcing of such compounds is key to advancing chemical discovery.

In essence, 1,3-dimethyl-5-iodobenzene is a critical component in the toolkit of organic chemists, enabling the creation of diverse and valuable molecules through its versatile reactivity.