Understanding the synthesis and intrinsic properties of key chemical intermediates is fundamental to their effective utilization in research and industrial applications. 3-Bromo-2-(trifluoromethyl)pyridine, bearing the CAS number 590371-58-7, is a prime example of a versatile building block whose properties dictate its widespread use. At NINGBO INNO PHARMCHEM CO.,LTD., we focus on providing high-purity materials that empower chemists in their synthetic endeavors.

The synthesis of 3-Bromo-2-(trifluoromethyl)pyridine can be achieved through various routes, often involving the selective functionalization of pyridine rings. One common approach involves the trifluoromethylation of bromopyridines or the bromination of trifluoromethylpyridines. Researchers have explored methods that utilize trifluoromethylating reagents in conjunction with appropriate precursors to install the CF3 group, followed by regioselective bromination. The precise control over reaction conditions is paramount to achieving high yields and purity, ensuring that the resulting 3-Bromo-2-(trifluoromethyl)pyridine is suitable for demanding applications.

The physical and chemical properties of 3-Bromo-2-(trifluoromethyl)pyridine are central to its role as an organic synthesis intermediate. It typically presents as a white to light yellow solid or liquid, with a melting point in the range of 34-36°C and a boiling point of 97-99°C at 35 Torr. Its molecular formula is C6H3BrF3N, with a molecular weight of approximately 225.99 g/mol. The presence of both the bromine atom and the trifluoromethyl group imparts distinct reactivity patterns. The bromine atom acts as a good leaving group in nucleophilic substitution and is highly amenable to palladium-catalyzed cross-coupling reactions, a cornerstone of modern synthetic organic chemistry. The trifluoromethyl group, being strongly electron-withdrawing, influences the electron density distribution within the pyridine ring, activating or deactivating specific positions towards electrophilic or nucleophilic attack, respectively.

These properties make 3-Bromo-2-(trifluoromethyl)pyridine an invaluable reagent for creating more complex molecules. Its utility as a chemical synthesis building block is evident in its application in creating compounds like 2-(trifluoromethyl)nicotinic acid. The ability to reliably purchase 3-Bromo-2-(trifluoromethyl)pyridine with consistent quality from a trusted supplier like NINGBO INNO PHARMCHEM CO.,LTD. is critical for researchers seeking to accelerate their projects. Whether for academic research exploring new reaction mechanisms or for industrial R&D aiming to develop novel pharmaceuticals or materials, the availability and understanding of this compound's synthesis and properties are essential.

By providing access to such key organic synthesis intermediates, NINGBO INNO PHARMCHEM CO.,LTD. contributes to the advancement of chemical science. Our dedication to quality ensures that scientists can confidently incorporate 3-Bromo-2-(trifluoromethyl)pyridine into their synthetic strategies, driving innovation and discovery.