Solid Phase Peptide Synthesis (SPPS) has revolutionized the way scientists create peptides, enabling the efficient production of complex molecules used in therapeutics, diagnostics, and research. Central to the success of modern SPPS is the use of the fluorenylmethyloxycarbonyl (FMOC) protecting group strategy, with 9-Fluorenylmethyl Chloroformate (FMOC-Cl), CAS 28920-43-6, being the key reagent for its introduction. NINGBO INNO PHARMCHEM CO.,LTD. supplies high-quality FMOC-Cl to support this vital area of chemical synthesis.

The principle behind FMOC-based SPPS is straightforward yet powerful. A protected amino acid is coupled to a growing peptide chain attached to an insoluble solid support. The FMOC group serves as a temporary protecting group for the alpha-amino function of the amino acid. This protection is crucial because it prevents the amino group from reacting prematurely during the coupling process. Once the coupling is complete, the FMOC group is selectively removed using a mild base, typically piperidine. This deprotection step exposes a free amine group on the last added amino acid, ready for the next coupling cycle.

The advantages of using FMOC-Cl in solid phase peptide synthesis are numerous. The FMOC group is stable under acidic conditions, which are often used to cleave the final peptide from the solid support and remove side-chain protecting groups. Conversely, it is easily removed by mild bases, which are compatible with most amino acid side chains and the solid support. This orthogonality simplifies the synthesis protocol and minimizes the risk of side reactions or racemization. This makes FMOC-Cl a preferred reagent for achieving high yields and purities in peptide synthesis.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing FMOC-Cl that meets the stringent requirements of peptide chemists. Our product's high purity and consistent quality ensure reliable performance in your SPPS protocols. Whether you are developing novel peptide-based therapeutics, synthesizing peptides for immunological studies, or creating peptides for cosmetic applications, our FMOC-Cl is the reliable choice. Trust NINGBO INNO PHARMCHEM CO.,LTD. to supply the essential building blocks for your peptide synthesis needs.