Glutaric acid (CAS 110-94-1) plays a complex role in human health, being both a naturally occurring metabolite and a potential indicator of certain metabolic dysfunctions. Understanding its presence and levels within the body is crucial for medical diagnostics and research into metabolic disorders.

As a product of amino acid metabolism, Glutaric acid is part of the body's natural biochemical processes, specifically in the breakdown of lysine and tryptophan. Its presence in biological fluids like blood, urine, and cerebrospinal fluid is normal within certain ranges. However, elevated levels can signal underlying health issues.

One of the most significant associations of abnormal Glutaric acid levels is with Glutaric Aciduria Type I (GA1). This inherited metabolic disorder results from a deficiency in the enzyme glutaryl-CoA dehydrogenase, leading to the accumulation of Glutaric acid and other toxic intermediates. This accumulation can cause severe neurological damage, particularly in infants, often manifesting as macrocephaly. The detection of high Glutaric acid levels in urine or blood is a key diagnostic marker for GA1, emphasizing its importance as a biomarker in clinical biochemistry. Research into GA1 often involves detailed studies of Glutaric acid metabolism.

Beyond GA1, studies suggest that Glutaric acid may also be elevated in other conditions, including certain neurodevelopmental disorders and in individuals with riboflavin (Vitamin B2) deficiency. This broadens the scope of Glutaric acid as a potential marker for various physiological states. The analysis of organic acids, including Glutaric acid, is a vital tool for healthcare professionals seeking to understand a patient's metabolic status.

The scientific community continues to explore the intricate connections between Glutaric acid levels and overall health. Advances in analytical techniques allow for more precise measurement of Glutaric acid in various biological samples, aiding in both research and clinical diagnosis. As a supplier of high-quality chemical reagents, we provide Glutaric acid for laboratory use, supporting critical research in metabolism and disease diagnostics. Accurate measurements of Glutaric acid are indispensable for understanding these health implications.