At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical importance of reliable and high-quality chemical intermediates. Among these, 5-Chloropyridine-2-carboxylic Acid (CAS 86873-60-1) stands out as a cornerstone for innovation in the pharmaceutical and agrochemical sectors. Our expertise lies in developing and refining synthesis methods to ensure consistent purity and yield, meeting the demanding standards of modern chemical manufacturing.

The most established and widely adopted route for synthesizing 5-Chloropyridine-2-carboxylic Acid involves the alkaline hydrolysis of 5-chloro-2-cyanopyridine. This process, typically carried out using a 10% aqueous solution of sodium hydroxide in ethanol under reflux conditions (90-100°C for approximately 1.5 hours), offers a robust pathway to achieve high yields, often exceeding 80%. This method is favored for its operational simplicity and scalability, making it a go-to choice for industrial production. The reaction proceeds through the nucleophilic attack of hydroxide ions on the nitrile group, forming a carboxylate intermediate, which is subsequently acidified with HCl to precipitate the final product. Purification often involves recrystallization from a mixture of methanol and dichloromethane, ensuring a high-purity crystalline powder.

While the hydrolysis method is efficient, NINGBO INNO PHARMCHEM CO.,LTD. also investigates alternative and greener synthesis approaches. Palladium-catalyzed alkyne oxidation presents a more modern pathway, starting from 2,5-dichloropyridine. This method involves coupling with a terminal alkyne, followed by oxidation of the resulting alkynylpyridine. Although potentially yielding slightly lower, yet still significant, yields, this approach offers better functional group tolerance and avoids the harsh conditions of hydrolysis. Furthermore, it aligns with our commitment to sustainable chemistry by minimizing the use of harsh reagents and exploring more environmentally benign processes.

Understanding the price and availability of 5-Chloropyridine-2-carboxylic Acid is crucial for our clients. We strive to offer competitive pricing for this essential intermediate, ensuring that our partners can procure it reliably for their research and development needs. Whether you are looking to buy 5-Chloropyridine-2-carboxylic Acid for early-stage research or large-scale manufacturing, NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to being your trusted supplier. Our deep understanding of the 5-chloropyridine-2-carboxylic acid synthesis process allows us to guarantee product quality and provide technical support.

As a leading provider of chemical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. is continuously working to optimize the production of 5-Chloropyridine-2-carboxylic Acid. Our goal is to support the advancement of pharmaceutical and agrochemical industries by providing essential building blocks that drive innovation and deliver tangible benefits to society.