N-Methylaniline (NMA), identified by CAS 100-61-8, is a prominent organic compound with a chemical formula of C7H9N. This secondary amine, characterized by its pale yellow to brownish oily liquid appearance and a subtle amine odor, is a derivative of aniline. Its industrial significance stems from its dual role as a solvent and a critical intermediate in various chemical synthesis pathways.

The synthesis of N-Methylaniline typically involves the alkylation of aniline. One common method is the reaction of aniline with dimethyl sulfate, where dimethyl sulfate is added dropwise to a chilled mixture of aniline and water, followed by treatment with sodium hydroxide. This process yields a mixture of aniline, N-methylaniline, and N,N-dimethylaniline, which are then separated. Alternative synthesis routes include the hydroalkylation of nitrobenzene with methanol over modified oxide catalysts, where promoting catalysts with chromium can enhance selectivity towards N-methylaniline. Research also explores methods using reagents like triethylborane and triethoxysilane under specific conditions to achieve high yields.

Industrially, N-Methylaniline serves multiple purposes. It functions as a latent and coupling solvent, aiding in various chemical reactions and formulations. More critically, it acts as a versatile intermediate for manufacturing a broad spectrum of products. Its applications span across the production of dyes and pigments, contributing to vibrant colors in textiles and inks. In the rubber industry, it's a precursor for vulcanization accelerators and antioxidants that improve rubber's durability. The pharmaceutical sector utilizes NMA as a building block for synthesizing drugs, including those for hypertension and anti-inflammatory treatments. Furthermore, it's a key raw material in the agrochemical industry for producing herbicides and fungicides, and in the polymer industry as an antioxidant, antiozonant, and chain-transfer agent.

For businesses requiring N-Methylaniline, ensuring a stable and high-quality supply is crucial. NINGBO INNO PHARMCHEM CO.,LTD. stands as a reliable provider of N-Methylaniline, offering products that meet industry standards. Understanding the various synthesis methods and the extensive applications of N-Methylaniline highlights its indispensable position in modern chemical manufacturing.