At NINGBO INNO PHARMCHEM CO.,LTD., we understand the critical role of the gut microbiome in overall health. Our research into dietary nucleotides has revealed their significant potential as prebiotics, compounds that selectively stimulate the growth and/or activity of beneficial bacteria in the gut. This prebiotic function not only enhances digestive health but also plays a pivotal role in bolstering the immune system.

Scientific studies, particularly those involving animal models, have demonstrated that nucleotide supplementation can significantly alter the composition of the gut microbiota. This includes increasing the diversity of bacterial species and promoting the proliferation of beneficial bacteria such as Lactobacillus and Bifidobacterium. These microorganisms are known to produce short-chain fatty acids (SCFAs), which are vital for maintaining the integrity of the intestinal lining, providing energy to colonocytes, and exerting anti-inflammatory effects. The ability of nucleotides to support the growth of these beneficial microbes highlights their prebiotic capabilities.

The impact of nucleotides on gut health extends to their role in strengthening the immune system. The gut is a major site of immune activity, and a healthy microbiota is essential for proper immune development and function. Nucleotides are crucial components for rapidly dividing cells, including immune cells. By providing a readily available source of nucleotides, supplementation can support the proliferation and activity of lymphocytes and other immune cells, thereby enhancing the host's ability to fight off infections and maintain immune homeostasis. This is particularly important during periods of stress or disease challenge, where nutrient demands for immune function increase.

Furthermore, research has shown that nucleotides can improve the gut's resilience against pathogens. For instance, studies have indicated that nucleotides can promote the growth of probiotics like *Lactobacillus casei*, enhancing their ability to form biofilms and produce substances that inhibit the growth of pathogenic bacteria such as *Shigella*. This dual action—supporting beneficial bacteria while potentially hindering harmful ones—underscores the comprehensive role of nucleotides in maintaining a healthy gut ecosystem. This makes them a valuable ingredient for dietary supplements and functional foods.

The implications for animal nutrition are substantial, with nucleotide supplementation being recognized as a way to improve growth performance, feed efficiency, and disease resistance in livestock and aquaculture. For human nutrition, the benefits are equally compelling, with applications ranging from infant formulas to dietary supplements aimed at improving gut health and immune function in all age groups. Our commitment at NINGBO INNO PHARMCHEM CO.,LTD. is to provide high-quality nucleotide products that empower formulators to harness these prebiotic and immunomodulatory benefits.

As the understanding of the gut microbiome continues to expand, the role of dietary nucleotides as functional ingredients will undoubtedly grow. Their ability to act as prebiotics and support robust immune function makes them an attractive option for companies seeking to develop innovative products that promote gut health and overall wellness.