NINGBO INNO PHARMCHEM CO.,LTD. is committed to advancing chemical research by providing high-quality compounds and detailed technical information. This article explores the preparation methods and analytical techniques employed for 1H,1H,13H-Perfluorotridecan-1-ol, CAS number 423-72-3.

The synthesis of 1H,1H,13H-Perfluorotridecan-1-ol typically involves multi-step processes to achieve its complex perfluorinated structure. One primary method is telomerization, where perfluoroalkyl iodides react with ethylene oxide, followed by a reduction step to yield the desired alcohol. This process requires carefully controlled reaction conditions, often involving elevated temperatures and specific solvents like benzotrifluoride or diethyl ether, to manage the reactivity of perfluorinated intermediates.

Alternative synthetic routes include the iodination of precursors followed by reduction. For instance, perfluorinated iodides can be reduced using reagents such as tributyltin hydride under thermal conditions to produce the fluorinated alcohol. The choice of synthetic route often depends on factors like yield, purity requirements, and the availability of starting materials. Post-synthesis purification is a critical stage, typically involving techniques such as column chromatography and recrystallization to isolate the high-purity 99% product.

Accurate characterization is essential for confirming the identity and purity of 1H,1H,13H-Perfluorotridecan-1-ol. Nuclear Magnetic Resonance (NMR) spectroscopy is a cornerstone technique. Proton NMR (¹H NMR) provides signals for the terminal methylene and hydroxyl protons, while fluorine-19 NMR (¹⁹F NMR) offers detailed insights into the extensive fluorination pattern. The unique chemical shifts and coupling patterns observed in ¹⁹F NMR spectra are definitive identifiers for perfluorinated compounds.

Mass Spectrometry (MS), particularly when coupled with gas chromatography (GC-MS) or liquid chromatography (LC-MS/MS), is vital for determining the molecular weight and fragmentation patterns. High-resolution mass spectrometry (HRMS) allows for precise mass determination, confirming the molecular formula C₁₃H₄F₂₄O and the CAS number 423-72-3. Infrared (IR) and Raman spectroscopy provide complementary vibrational data, confirming the presence of functional groups like the hydroxyl group and the numerous carbon-fluorine bonds, creating a unique spectroscopic fingerprint for 1H,1H,13H-Perfluorotridecan-1-ol.

Researchers at NINGBO INNO PHARMCHEM CO.,LTD. utilize these advanced analytical techniques to ensure the quality and consistency of their products. Understanding these preparation and characterization methods is key for anyone working with this important pharmaceutical chemical or related fluorinated compounds. The successful synthesis and reliable analysis of CAS 423-72-3 are fundamental to its application in cutting-edge research and development.