Understanding the Properties and Handling of Allylboronic Acid Pinacol Ester
Effective utilization of any chemical reagent begins with a thorough understanding of its properties and proper handling procedures. Allylboronic Acid Pinacol Ester (CAS 72824-04-5) is a powerful tool in organic synthesis, but like many reactive compounds, it requires careful management. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of this knowledge for safe and successful applications.
Allylboronic Acid Pinacol Ester is typically presented as a colorless to pale yellow liquid. Its molecular formula is C9H17BO2, with a molecular weight of approximately 168.04 g/mol. The presence of the pinacol group lends it greater stability compared to simpler boronic acids, making it more resistant to degradation under typical laboratory conditions. However, it is important to note its sensitivity to moisture, which can lead to hydrolysis of the boron-oxygen bonds.
Key physical properties include a boiling point of around 50-53°C at 5 mmHg and a density of 0.896 g/mL. Crucially, it has a flash point of 46°C, classifying it as a flammable liquid. This necessitates storage in a cool, dry, well-ventilated area, away from ignition sources. Storage under an inert atmosphere, such as nitrogen or argon, is highly recommended to preserve its integrity and prevent moisture ingress.
In terms of chemical reactivity, Allylboronic Acid Pinacol Ester is a potent allylating agent. Its primary applications revolve around carbon-carbon bond formation, most notably in Suzuki-Miyaura cross-coupling reactions. It also participates in the allylation of carbonyl compounds, yielding valuable homoallylic alcohols. These transformations are foundational for constructing complex organic molecules, including pharmaceutical intermediates.
When considering to buy Allylboronic Acid Pinacol Ester, understanding these properties is vital. Always ensure you are working in a well-ventilated fume hood, wearing appropriate personal protective equipment, including gloves, eye protection, and protective clothing. For any specific inquiries regarding safe handling or product specifications, consulting the Material Safety Data Sheet (MSDS) and reaching out to NINGBO INNO PHARMCHEM CO.,LTD. for technical support is advisable. Proper storage and handling are key to unlocking the full synthetic potential of this invaluable reagent.
Perspectives & Insights
Chem Catalyst Pro
“However, it is important to note its sensitivity to moisture, which can lead to hydrolysis of the boron-oxygen bonds.”
Agile Thinker 7
“Key physical properties include a boiling point of around 50-53°C at 5 mmHg and a density of 0.”
Logic Spark 24
“This necessitates storage in a cool, dry, well-ventilated area, away from ignition sources.”