2-Amino-5-Iodobenzonitrile, bearing the CAS number 132131-24-9, is a compound of significant interest in the chemical industry, primarily for its utility as a versatile intermediate. Its molecular formula, C7H5IN2, and molecular weight of 244.03 g/mol, hint at its specific chemical reactivity and potential applications in complex syntheses.

This compound is characterized by its appearance as an off-white to yellow solid. Its melting point is typically observed in the range of 85-87°C, a physical property that is critical for handling and processing in synthetic procedures. The compound's solubility profile indicates it is very soluble in N,N-Dimethylformamide, soluble in methanol, sparingly soluble in glacial acetic acid, and practically insoluble in water. This solubility behavior is an important consideration when designing reaction and purification protocols, especially when sourcing from various chemical suppliers.

The primary application driving the demand for 2-Amino-5-iodobenzonitrile is its role as a key intermediate in the synthesis of pharmaceutical compounds. Specifically, it serves as a precursor for intermediates used in the production of lapatinib, a critical targeted therapy for cancer. This application highlights its importance in the pharmaceutical intermediate manufacturing sector. The compound's structure allows for the precise introduction of functional groups, making it invaluable for creating the complex molecular frameworks required for modern medicines.

Beyond pharmaceuticals, 2-Amino-5-iodobenzonitrile is recognized as a valuable fine chemical synthesis reagent. Its iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions, a cornerstone of modern organic synthesis for C-C and C-heteroatom bond formation. Researchers and manufacturers leverage these reactions to build intricate molecular structures for a wide array of applications, from materials science to agrochemicals. The availability of this compound from various global suppliers, including those specializing in specialty aromatic nitriles, ensures its accessibility for diverse research and development needs.

For those involved in custom chemical synthesis services, 2-Amino-5-iodobenzonitrile represents a reliable building block. Its well-defined properties and established synthetic utility mean that it can be efficiently incorporated into tailored synthetic routes to create bespoke chemical entities. The consistent quality and purity offered by manufacturers of this 2-Cyano-4-iodoaniline are essential for reproducible results in research and scaled-up production.

In conclusion, 2-Amino-5-Iodobenzonitrile is a critical chemical intermediate whose properties and reactivity make it indispensable in the pharmaceutical and fine chemical industries. Its role in synthesizing vital drugs and facilitating complex organic transformations underscores its significance in driving scientific and industrial progress.