Tert-Butyl Acetoacetate (CAS: 1694-31-1) is a compound of significant interest in organic chemistry due to its versatile reactivity and broad applicability. Understanding its fundamental chemical properties and efficient synthesis pathways is key to leveraging its full potential in various industrial and research applications.

As a clear, colorless liquid, Tert-Butyl Acetoacetate possesses a molecular formula of C8H14O3 and a molecular weight of approximately 158.195 g/mol. Its physical characteristics include a melting point of -38°C and a boiling point of 190°C. The compound exhibits limited solubility in water, with approximately 9g/L, but is readily soluble in common organic solvents. Its refractive index is recorded as n20/D 1.419, and it has a flash point of 150°F, indicating it is a combustible liquid that requires careful handling and storage away from ignition sources.

The synthesis of Tert-Butyl Acetoacetate can be achieved through several established methods. A common industrial approach involves the transesterification of acetoacetic esters with tert-butyl alcohol, often catalyzed by acids like sulfuric acid. Another viable method involves the reaction of ketene with tert-butyl alcohol. These synthesis routes ensure that Tert-Butyl Acetoacetate is accessible for both laboratory-scale research and large-scale industrial production. Reliable suppliers, such as NINGBO INNO PHARMCHEM CO.,LTD., play a vital role in making this compound readily available to the market.

The chemical structure of Tert-Butyl Acetoacetate, featuring a β-keto ester moiety, confers significant reactivity. This makes it an excellent acetoacetylating reagent, capable of reacting with nucleophiles such as alcohols and amines. Its performance in these reactions often exceeds that of simpler acetoacetate esters, leading to improved yields and efficiency in producing various chemical intermediates. This characteristic is particularly valued in the pharmaceutical and coatings industries, where precise chemical transformations are critical.

For procurement professionals and researchers, sourcing Tert-Butyl Acetoacetate from reputable manufacturers is essential for ensuring product quality and consistency. NINGBO INNO PHARMCHEM CO.,LTD. is recognized as a leading supplier, providing access to this important chemical intermediate. Their commitment to quality ensures that users can rely on Tert-Butyl Acetoacetate for their demanding synthesis needs.