Understanding the intrinsic properties of a chemical compound is fundamental to predicting its behavior and optimizing its application in synthesis. 1-(2,4,6-Triisopropylphenylsulfonyl)imidazole (TPSI) is characterized by a set of physical and chemical attributes that define its role as a valuable reagent in various chemical processes. This article highlights these essential properties, shedding light on why TPSI is favored in demanding synthetic applications.

Physically, TPSI is described as a white crystal, indicating a solid state at standard room temperatures. Its melting point, typically ranging between 118-120°C, further solidifies this observation and suggests good thermal stability under moderate conditions. The compound exhibits a density of approximately 1.13 g/cm³, which is a common characteristic for many organic solids. Its refractive index, noted at 1.562, hints at its optical properties which can be relevant in certain analytical or physical characterization techniques.

Chemically, the defining feature of TPSI is its sulfonyl imidazole structure. This moiety is responsible for its reactivity as a leaving group and its ability to activate other molecules in condensation and coupling reactions. The presence of the bulky triisopropylphenyl group provides steric hindrance, influencing selectivity in chemical reactions. While generally stable, it is often recommended to store TPSI in a cool, dry, and well-ventilated place to maintain its purity and efficacy over time. Its sensitivity to moisture is also a factor to consider during handling and storage, emphasizing the need for tightly sealed containers.

The purity of TPSI is a critical specification, with high-Performance Liquid Chromatography (HPLC) typically used to assess it, often requiring levels of 98.0% or higher for synthetic applications. This high purity ensures that the reagent performs reliably and consistently, minimizing potential interference from impurities. When you buy 1-(2,4,6-Triisopropylphenylsulfonyl)imidazole, verifying its purity is a key step in ensuring successful experimental outcomes.

NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-quality chemical reagents like TPSI. We understand the importance of precise physical and chemical properties for our clients in pharmaceutical and fine chemical industries, and we are committed to delivering products that meet the highest standards of purity and performance.