At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to providing comprehensive information on the chemicals we supply, including their synthesis and proper handling. This article delves into 1,2-Dimethylimidazole-4-sulfonyl Chloride, identified by CAS 137049-02-6, a vital intermediate in organic synthesis and pharmaceutical research.

The synthesis of 1,2-Dimethylimidazole-4-sulfonyl Chloride typically involves the functionalization of a precursor imidazole ring. While specific proprietary synthesis routes may vary among manufacturers, common methods often involve the chlorosulfonation of a suitably substituted 1,2-dimethylimidazole. This process requires careful control of reaction conditions, including temperature, reagents, and solvents, to achieve high yields and purity. The resulting compound, often appearing as an off-white powder, possesses a molecular formula of C5H7ClN2O2S and a molecular weight of approximately 194.64 g/mol. Understanding the synthesis pathways ensures the availability of reliable and pure material for downstream applications.

Proper handling and storage of 1,2-Dimethylimidazole-4-sulfonyl Chloride are critical due to its inherent chemical properties. As a sulfonyl chloride, it is reactive towards nucleophiles and notably sensitive to moisture. This hygroscopic nature means that exposure to atmospheric humidity can lead to hydrolysis, forming the corresponding sulfonic acid and hydrochloric acid, thereby reducing the compound's purity and effectiveness. Therefore, it is imperative to store this chemical under an inert atmosphere, such as nitrogen or argon, in tightly sealed containers, and at recommended cool temperatures (typically 2-8°C). When researchers decide to buy this compound, they must be prepared to adhere to these strict storage requirements.

The applications of 1,2-dimethylimidazole-4-sulfonyl chloride are primarily as a building block in organic synthesis. Its reactive sulfonyl chloride group allows for the facile formation of sulfonamides, sulfonates, and other sulfur-containing functional groups, which are prevalent in many pharmaceuticals and specialty chemicals. The imidazole core itself is a significant pharmacophore found in numerous drugs. Consequently, this intermediate is highly valued in pharmaceutical research for the synthesis of novel drug candidates. Exploring various imidazole derivatives offers a pathway to discovering compounds with tailored biological activities.

NINGBO INNO PHARMCHEM CO.,LTD. ensures that all our products, including 1,2-dimethylimidazole-4-sulfonyl chloride (CAS 137049-02-6), meet stringent quality standards. Our commitment to providing high-purity chemicals, coupled with clear guidance on handling and storage, supports the success of our clients' research and development endeavors. By understanding both the synthesis and the crucial handling protocols, scientists can effectively leverage the synthetic potential of this important chemical intermediate.