Understanding the synthesis pathways and intrinsic properties of 4-Hydroxybenzaldehyde (CAS 123-08-0) is fundamental for optimizing its production and application. This versatile compound can be manufactured through several distinct chemical routes, each with its own advantages and considerations regarding yield, purity, and environmental impact. NINGBO INNO PHARMCHEM CO.,LTD. employs rigorous processes to ensure the production of high-quality 4-hydroxybenzaldehyde that meets stringent industry standards.

Several key methods are utilized for the synthesis of 4-hydroxybenzaldehyde. One common approach involves the Reimer-Tiemann reaction, using phenol and chloroform in an alkaline solution. Another route utilizes the reaction between phenol and hydrogen cyanide in the presence of a catalyst, followed by hydrolysis. Phenol can also react with chloral via condensation, which is then decomposed by sodium methylate. Alternative methods may involve starting materials like p-cresol or nitrotoluene, employing a series of reactions including chlorination, hydrolysis, reduction, and diazotization. Each of these synthesis methods requires careful control of reaction conditions to maximize yield and purity, crucial factors for downstream applications.

The physical properties of 4-hydroxybenzaldehyde are also vital for its handling and application. It typically appears as a white to pale yellow crystalline powder. Its melting point is around 115-116 °C. The compound exhibits good solubility in common organic solvents like alcohol, ether, acetone, and ethyl acetate, while being only slightly soluble in water. Its characteristic aromatic odor contributes to its use in the fragrance industry. Understanding these properties is essential for chemists and engineers working with this compound, whether in research, development, or large-scale manufacturing. NINGBO INNO PHARMCHEM CO.,LTD. focuses on producing 4-hydroxybenzaldehyde with consistent physical characteristics to ensure reliable performance in all its intended uses.