The world of organic chemistry relies heavily on a diverse array of molecular building blocks, each possessing unique properties that enable the construction of complex chemical structures. Among these indispensable intermediates is 1,3-dimethyl-5-iodobenzene (CAS No: 22445-41-6), a compound whose structure and reactivity make it highly valuable for synthetic chemists.

Understanding the Chemical Makeup

1,3-Dimethyl-5-iodobenzene, also referred to as 1-Iodo-3,5-dimethylbenzene, is an aromatic compound characterized by a benzene ring substituted with an iodine atom and two methyl groups. Its molecular formula is C8H9I, and it has a molecular weight of 232.061. The physical characteristics are noteworthy: it appears as a pink-brown to red transparent liquid, with a density of approximately 1.6 g/cm³ and a boiling point around 230 °C. Crucially, its assay is typically specified as ≥98.0%, signifying high purity, which is essential for predictable outcomes in chemical reactions.

The Reactivity of an Aryl Iodide

As an aryl iodide, 1,3-dimethyl-5-iodobenzene is highly prized for its utility in cross-coupling reactions. The carbon-iodine bond is more labile than carbon-bromine or carbon-chlorine bonds, allowing for facile oxidative addition to transition metal catalysts, such as palladium. This makes it an excellent substrate for reactions like the Suzuki-Miyaura coupling (forming C-C bonds), the Heck reaction, and the Sonogashira coupling. These transformations are fundamental for creating intricate molecular architectures found in pharmaceuticals, agrochemicals, and advanced materials. The presence of the methyl groups also influences the regioselectivity and reactivity of these processes.

Procuring High-Quality Intermediates

For researchers and chemical engineers, the consistent availability of high-purity 1,3-dimethyl-5-iodobenzene from reputable suppliers is critical. When considering the purchase of this compound, factors such as purity specifications (≥98.0%), packaging options (e.g., 200 kg/drum), and storage recommendations (cool, ventilated place) are important. Engaging with a trusted manufacturer ensures that the material meets the stringent requirements for advanced organic synthesis, allowing for reliable experimental design and execution. Exploring various prices and availability options can also help optimize budgets for research and development projects.

Applications in Synthesis and Beyond

The primary application of 1,3-dimethyl-5-iodobenzene is as a synthetic intermediate. It serves as a building block for creating more complex organic molecules with tailored properties. Its role in facilitating carbon-carbon bond formation is particularly significant, enabling the synthesis of compounds that are difficult to access through other means. This makes it a valuable reagent in academic research, pharmaceutical development, and the production of specialized fine chemicals.

In summary, 1,3-dimethyl-5-iodobenzene is a cornerstone intermediate in modern organic synthesis, owing to its well-defined properties and versatile reactivity. Its reliable procurement from trusted sources underscores its importance in enabling scientific innovation and chemical product development.