NINGBO INNO PHARMCHEM CO.,LTD. is proud to highlight the indispensable contribution of N-(tert-Butoxycarbonyl)-p-toluenesulfonamide (CAS: 18303-04-3) to the field of organic synthesis. This compound, characterized by its molecular formula C12H17NO4S and a molecular weight of 271.33, presents as a fine white to almost white powder, readily soluble in chloroform, and stable at room temperature when stored properly. Its utility extends across several critical organic transformations, making it a cornerstone for researchers and manufacturers alike.

One of the most significant applications of N-(tert-Butoxycarbonyl)-p-toluenesulfonamide lies in its role as a key precursor in the Pauson-Khand reaction. This powerful [2+2+1] cycloaddition reaction is instrumental in synthesizing cyclopentenones, which are fundamental building blocks for a vast array of natural products and complex organic molecules. The ability of N-(tert-Butoxycarbonyl)-p-toluenesulfonamide to participate effectively in this reaction significantly streamlines synthetic pathways, allowing for the efficient construction of intricate carbon frameworks. Researchers often seek high-quality organic synthesis intermediates like this to ensure the success and efficiency of their complex synthetic targets.

Furthermore, N-(tert-Butoxycarbonyl)-p-toluenesulfonamide serves as a valuable reagent in Mitsunobu reactions. These reactions are celebrated for their ability to invert stereochemistry and facilitate nucleophilic substitution under mild conditions. Specifically, this compound enables the direct coupling with primary, secondary, and allylic alcohols to yield various sulfonyl-protected amines. This functionalization is crucial in multi-step syntheses, offering a reliable method for introducing protected amino groups. The demand for such specialized reagents underscores the importance of sourcing high-purity chemicals to achieve predictable and reproducible results in laboratory and industrial settings. Understanding the uses of N-substituted sulfonamides is key for chemists aiming to develop novel synthetic strategies.

The compound's versatility also extends to the preparation of enyne amides, further broadening its applicability in complex molecule construction. As a reliable fine chemical intermediate, N-(tert-Butoxycarbonyl)-p-toluenesulfonamide is essential for academic research and the development of new chemical entities. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing high-purity N-(tert-Butoxycarbonyl)-p-toluenesulfonamide to support these vital scientific endeavors. The efficient synthesis of N-(tert-Butoxycarbonyl)-p-toluenesulfonamide and its consistent availability are critical for advancing research in areas such as medicinal chemistry and materials science.