The Role of Boc-D-His(Bom)-OH in Advancing Peptide Synthesis
In the sophisticated realm of peptide synthesis, the careful selection of building blocks is paramount to achieving high-quality and functional peptide sequences. Among these crucial components, protected amino acids stand out, and Boc-D-His(Bom)-OH (CAS 99310-01-7) has emerged as a vital player. This derivative of D-histidine, featuring both a tert-butyloxycarbonyl (Boc) and a benzyloxymethyl (Bom) protecting group, offers unique advantages for chemists engaged in complex peptide construction.
The primary utility of Boc-D-His(Bom)-OH lies in its role as a protected amino acid for peptide synthesis. The Boc group is a standard N-terminal protecting group, readily removed under mild acidic conditions. The Bom group, on the other hand, protects the imidazole side chain of histidine. This dual protection strategy allows for orthogonal deprotection, meaning one protecting group can be removed without affecting the other, providing chemists with precise control over the synthesis process. This level of control is essential when assembling long and complex peptide chains, where specific amino acid residues need to be modified or coupled at different stages.
For researchers looking to buy Boc-D-His(Bom)-OH online, understanding its specifications is key. With a molecular formula of C19H25N3O5 and a molecular weight of approximately 375.42 g/mol, this compound is typically supplied as a white powder. Its physical properties, such as a density of 1.21 g/cm³, a boiling point of 595.3°C, and a flash point of 313.8°C, are important considerations for handling and storage. The reliable sourcing of such chemicals is critical for consistent experimental outcomes and efficient production.
The demand for Boc-D-His(Bom)-OH as a synthesis reagent is driven by the burgeoning field of peptide therapeutics and research. Pharmaceutical development increasingly relies on precisely synthesized peptides to create new drugs and diagnostic tools. This makes reliable N-tert-Butyloxycarbonyl-N'-benzyloxymethyl-D-histidine suppliers indispensable partners for research institutions and biotechnology companies. Whether for academic research or industrial application, the availability of high-purity Boc-D-His(Bom)-OH facilitates innovation.
The process of custom peptide synthesis often involves specific modifications or the incorporation of non-natural amino acids. Boc-D-His(Bom)-OH fits perfectly into these advanced synthesis strategies. Its availability through various chemical suppliers, often with competitive Boc-D-His(Bom)-OH CAS 99310-01-7 price points, ensures that researchers can access this essential building block for their demanding projects. As the field of peptide science continues to expand, the importance of compounds like Boc-D-His(Bom)-OH will only grow, underpinning breakthroughs in medicine and beyond.
Perspectives & Insights
Logic Thinker AI
“The Boc group is a standard N-terminal protecting group, readily removed under mild acidic conditions.”
Molecule Spark 2025
“This dual protection strategy allows for orthogonal deprotection, meaning one protecting group can be removed without affecting the other, providing chemists with precise control over the synthesis process.”
Alpha Pioneer 01
“This level of control is essential when assembling long and complex peptide chains, where specific amino acid residues need to be modified or coupled at different stages.”