The Role of Boc-D-Phe(4-CN)-OH in Modern Peptide Therapeutics
In the dynamic field of pharmaceutical research, the development of novel peptide-based therapeutics continues to gain momentum. Central to this progress is the availability of specialized amino acid derivatives that allow chemists to fine-tune the properties of therapeutic peptides. Among these, Boc-D-Phe(4-CN)-OH, or N-Boc-4-cyano-D-phenylalanine, stands out as a critical component. This modified amino acid, identified by its CAS number 146727-62-0, offers unique advantages that are significantly impacting drug development pipelines. NINGBO INNO PHARMCHEM CO.,LTD. is proud to contribute to this advancement by providing high-quality Boc-D-Phe(4-CN)-OH for researchers and manufacturers.
The primary utility of Boc-D-Phe(4-CN)-OH in peptide synthesis lies in its ability to introduce a cyano group onto the phenyl ring of the D-phenylalanine residue. This modification is not merely structural; it critically influences the peptide's pharmacodynamics and pharmacokinetics. The electron-withdrawing nature of the cyano group can alter the peptide's conformation, receptor binding affinity, and metabolic stability. For instance, incorporating this residue might lead to peptides with improved potency or longer half-lives in vivo. Researchers aiming to buy Boc-D-Phe(4-CN)-OH are often seeking these specific property enhancements for their drug candidates. Understanding the correct peptide synthesis building blocks is key to successful outcomes.
Beyond its direct impact on peptide structure, the Boc (tert-butyloxycarbonyl) protecting group on the alpha-amino nitrogen is essential for controlled peptide assembly. This group ensures that the amino acid can be selectively coupled to a growing peptide chain during solid-phase peptide synthesis (SPPS) or solution-phase methods. The protective group strategy is fundamental to preventing unwanted side reactions and ensuring the synthesis of high-purity peptides. This makes Boc-D-Phe(4-CN)-OH an indispensable reagent for those engaged in custom peptide manufacturing. The availability of reliable Boc-D-Phe(4-CN)-OH suppliers is paramount for consistent research and production.
The applications of Boc-D-Phe(4-CN)-OH extend into various therapeutic areas. In drug development, it has shown promise in the design of compounds targeting specific biological pathways, such as those involved in cancer therapy or neurological disorders. Its incorporation into peptide mimetics or peptide-drug conjugates allows for the creation of molecules with enhanced specificity and efficacy. Furthermore, the cyano functionality can serve as a handle for further chemical modifications or bioconjugation, enabling the development of targeted drug delivery systems. The price of Boc-D-Phe(4-CN)-OH can vary depending on purity and supplier, but its value in accelerating drug discovery is substantial.
The reliable supply of high-quality modified amino acids like Boc-D-Phe(4-CN)-OH is crucial for the pharmaceutical industry. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing consistent quality and support to researchers. By understanding the importance of these chemical intermediates for pharmaceuticals, we aim to empower innovation in peptide therapeutics. Whether for early-stage research or large-scale production, the precise incorporation of Boc-D-Phe(4-CN)-OH facilitates the development of next-generation medicines, addressing unmet medical needs with advanced chemical solutions.
Perspectives & Insights
Logic Thinker AI
“The price of Boc-D-Phe(4-CN)-OH can vary depending on purity and supplier, but its value in accelerating drug discovery is substantial.”
Molecule Spark 2025
“The reliable supply of high-quality modified amino acids like Boc-D-Phe(4-CN)-OH is crucial for the pharmaceutical industry.”
Alpha Pioneer 01
“By understanding the importance of these chemical intermediates for pharmaceuticals, we aim to empower innovation in peptide therapeutics.”