At NINGBO INNO PHARMCHEM CO., LTD., we are dedicated to advancing scientific understanding and application of key chemical compounds. One such compound that has garnered significant attention in the fields of metabolic health and diagnostics is Beta-Hydroxyisovaleric Acid, often abbreviated as BHIVA, identified by its CAS number 625-08-1.

Beta-Hydroxyisovaleric Acid is a metabolite derived from leucine, an essential branched-chain amino acid. Its presence and levels in the body are closely linked to critical metabolic pathways, making it a valuable subject of study for researchers and clinicians alike. The intricate leucine metabolism pathways highlight BHIVA's role not just as a byproduct but as an indicator of underlying metabolic functions.

One of the most significant aspects of BHIVA is its utility as a biomarker for biotin deficiency. Biotin, a vital B vitamin, acts as a cofactor for several carboxylase enzymes, including methylcrotonyl-CoA carboxylase, which is crucial for leucine breakdown. When biotin levels are insufficient, the activity of this enzyme is impaired, leading to an accumulation of metabolites that are shunted into alternative pathways, resulting in elevated urinary levels of Beta-Hydroxyisovaleric Acid. This makes BHIVA a sensitive indicator for identifying marginal or overt biotin deficiencies, which can impact energy metabolism and overall health.

Furthermore, BHIVA is intrinsically linked to various metabolic disorders. Notably, its levels are significantly elevated in conditions like Maple Syrup Urine Disease (MSUD), a rare genetic disorder affecting the metabolism of branched-chain amino acids. Understanding the beta-hydroxyisovaleric acid uses in diagnosing these conditions is paramount for early intervention and management. Researchers are continuously exploring the nuances of these metabolic disorders, seeking to refine diagnostic tools and therapeutic strategies.

The compound's relevance extends into the pharmaceutical sector. As a key intermediate, BHIVA serves as a building block in the synthesis of various pharmaceutical compounds. Its specific chemical structure and reactivity allow for its incorporation into complex molecular architectures, supporting the development of new therapeutic agents. The demand for high-purity Beta-Hydroxyisovaleric Acid in pharmaceutical synthesis underscores its importance in drug discovery and manufacturing processes. Purchasing this compound from reliable suppliers ensures the quality and consistency required for these critical applications.

At NINGBO INNO PHARMCHEM CO., LTD., we provide high-quality Beta-Hydroxyisovaleric Acid to support your research and development needs. Our commitment to excellence ensures that you receive a product that meets stringent quality standards, enabling groundbreaking discoveries and advancements in metabolic health, diagnostics, and pharmaceuticals.