A deep understanding of chemical properties is fundamental to leveraging any compound effectively in synthesis. At NINGBO INNO PHARMCHEM CO.,LTD., we pride ourselves on providing high-purity intermediates with well-characterized attributes. This article focuses on the essential chemical properties of propyl 2-bromoacetate, also known as propyl bromoacetate (CAS 35223-80-4), and its importance as a versatile organic synthesis intermediate.

Propyl 2-bromoacetate, identified by CAS 35223-80-4, is a key organic compound with the molecular formula C5H9BrO2 and a molecular weight of 181.02800. Its physical form is typically a colorless to slightly yellow transparent liquid. The compound exhibits a density of approximately 1.39 g/cm³, a boiling point ranging from 175°C to 176°C, and a flash point of 82°C. These physical parameters are crucial for handling, storage, and process design in industrial settings.

From a chemical perspective, the standout feature of propyl 2-bromoacetate is the presence of a bromine atom on the alpha-carbon relative to the ester carbonyl group. This bromine atom is an excellent leaving group, making the alpha-carbon highly electrophilic. Consequently, the compound readily participates in nucleophilic substitution reactions, a cornerstone of organic synthesis. This inherent reactivity allows it to act as an alkylating agent, enabling the introduction of the propoxycarbonylmethyl group onto various nucleophiles.

The ester functionality (-COOCH2CH3) also contributes to the compound's versatility. It can undergo hydrolysis to yield bromoacetic acid and propanol, or participate in transesterification reactions to form different esters. These reactions expand the synthetic utility of propyl bromoacetate, allowing chemists to build more complex molecular architectures. For instance, its ability to form carbon-carbon bonds via reactions like the Reformatsky reaction makes it invaluable in constructing intricate organic frameworks, which are often the basis for pharmaceuticals and agrochemicals.

The high purity specification of propyl bromoacetate, typically ≥98.0% purity by gas chromatography, and a moisture content of ≤0.1%, are critical factors for its successful application. Impurities can interfere with reaction pathways, reduce yields, and compromise the quality of the final product. Therefore, when chemists seek to buy propyl bromoacetate, they prioritize sourcing from manufacturers like NINGBO INNO PHARMCHEM CO.,LTD. who guarantee these stringent quality standards.

In conclusion, the specific chemical properties of propyl 2-bromoacetate, particularly its electrophilic alpha-carbon and reactive ester group, position it as a vital organic synthesis intermediate. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing this high-quality compound, empowering chemists and manufacturers to achieve their synthetic goals in developing advanced materials and products.