Ethyl 3-aminocrotonate, a chemical compound identified by CAS number 626-34-6, is a fundamental building block in various chemical syntheses. Its unique structural features and reactivity make it a valuable intermediate in industries ranging from pharmaceuticals to agriculture. This article provides a detailed examination of its properties, common synthesis routes, and critical safety considerations for its handling.

The compound, often appearing as an off-white to light yellow solid with a melting point between 33-35°C, exhibits moderate solubility in water. Notably, Ethyl 3-aminocrotonate is sensitive to air and moisture, and it is hygroscopic. These characteristics underscore the importance of proper storage conditions, typically in sealed containers in a cool, dry, and well-ventilated environment, potentially under an inert atmosphere to preserve its quality and prevent degradation. Its boiling point is reported to be around 210-215°C at atmospheric pressure.

The synthesis of Ethyl 3-aminocrotonate is predominantly achieved through the reaction of ethyl acetoacetate with ammonia. This widely adopted Ethyl 3-aminocrotonate synthesis route is efficient and scalable, ensuring a steady supply for industrial demands. Advances in synthetic methodologies, including continuous flow chemistry, have further optimized production yields and purity, making it easier to buy Ethyl 3-aminocrotonate online.

As a versatile chemical intermediate, Ethyl 3-aminocrotonate serves multiple purposes. It is extensively used in organic synthesis for the creation of diverse chemical structures. Furthermore, it plays a vital role as a pharmaceutical intermediate, contributing to the development of various medicinal compounds. Its application extends to being a feed auxiliary agent, enhancing nutritional properties in animal feed. For those looking to source this compound, identifying reliable Ethyl 3-aminocrotonate suppliers is crucial for ensuring product quality and consistent availability.

Safe handling of Ethyl 3-aminocrotonate is paramount due to its potential hazards, which may include corrosivity and respiratory irritation. Users must consult Safety Data Sheets (SDS) provided by suppliers and adhere to recommended safety protocols. This includes wearing appropriate personal protective equipment (PPE) such as gloves, safety glasses, and respiratory protection. A thorough understanding of the Ethyl 3-aminocrotonate properties and potential risks allows for its safe and effective utilization in industrial and research settings. The diverse Ethyl 3-aminocrotonate uses highlight its importance across multiple scientific disciplines.