In the intricate field of biochemistry and pharmaceuticals, the precise construction of peptide chains is paramount. At the forefront of enabling this precision is 1-Hydroxy-7-azabenzotriazole, commonly known as HOAt. This powerful reagent has revolutionized peptide synthesis, offering superior efficiency and purity compared to its predecessors. NINGBO INNO PHARMCHEM CO.,LTD. is a dedicated supplier of high-quality HOAt, supporting researchers and manufacturers worldwide.

HOAt functions as a coupling additive, forming an activated ester with the carboxylic acid group of an amino acid. This activated ester is then highly reactive towards the amine group of the next amino acid in the growing peptide chain. What sets HOAt apart is its ability to suppress racemization – the unwanted conversion of one enantiomer into another – during the coupling process. This is particularly critical when synthesizing chiral amino acids, ensuring the final peptide maintains its correct stereochemistry and biological activity. The reliability of HOAt in minimizing epimerization makes it an indispensable tool for synthesizing complex and therapeutically important peptides.

The chemical structure of HOAt, 1-Hydroxy-7-azabenzotriazole (CAS: 39968-33-7), with its molecular formula C5H4N4O and a molecular weight of 136.11, contributes to its effectiveness. Typically appearing as a yellow crystalline powder, HOAt has a melting point around 213-216°C. While generally stable under recommended storage conditions, it's important to note its potential hazardous decomposition products, such as carbon monoxide and nitrogen oxides, underscoring the need for proper handling and safety protocols. NINGBO INNO PHARMCHEM CO.,LTD. ensures that its HOAt products meet stringent quality standards, providing comprehensive safety data sheets and product specifications to facilitate safe usage.

Beyond its primary role in peptide synthesis, HOAt has found applications in other areas of chemical research and industry. Its properties make it a candidate for use as a corrosion inhibitor, protecting metal surfaces from degradation, and as a photostabilizer in materials science, shielding them from UV damage. This versatility highlights the broader impact of advanced chemical reagents. For those looking to buy HOAt or source it for bulk orders, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive pricing and reliable supply chains, ensuring researchers can consistently access this vital compound for their groundbreaking work.

The increasing demand for synthetic peptides in drug discovery, diagnostics, and cosmetic applications continues to drive innovation in synthesis methodologies. HOAt plays a pivotal role in this progress, enabling the efficient and accurate creation of peptides with tailored functionalities. By providing high-purity HOAt, NINGBO INNO PHARMCHEM CO.,LTD. is committed to advancing scientific frontiers and supporting the development of novel peptide-based therapeutics and materials.