NINGBO INNO PHARMCHEM CO.,LTD. is at the forefront of supplying specialized chemical intermediates that empower scientific innovation. Among these, N-Fmoc-3-(1-naphthyl)-D-alanine stands out as a valuable reagent, particularly within the realms of peptide synthesis and organic chemistry.

N-Fmoc-3-(1-naphthyl)-D-alanine, identified by its CAS number 138774-93-3, is a protected chiral amino acid derivative. The 'N-Fmoc' prefix signifies the presence of the 9-fluorenylmethoxycarbonyl protecting group, a standard in solid-phase peptide synthesis (SPPS) for its ease of removal under mild basic conditions. The core of the molecule is D-alanine substituted with a 1-naphthyl group at the beta position, imparting unique steric and electronic characteristics.

The properties of N-Fmoc-3-(1-naphthyl)-D-alanine are critical for its effective utilization:

  • Molecular Formula and Weight: C28H23NO4, with a molecular weight of approximately 437.49 g/mol.
  • Appearance: Typically supplied as a white to off-white solid or powder.
  • Purity: High purity, often exceeding 98% by HPLC, is essential for reliable synthetic outcomes.
  • Chirality: The 'D' configuration is crucial for researchers aiming to build peptides with specific stereochemistry, which can influence biological activity and stability.

The utility of N-Fmoc-3-(1-naphthyl)-D-alanine is multifaceted:

  1. Peptide Synthesis: It serves as a key building block in the synthesis of peptides containing unnatural amino acids. The naphthyl group can enhance peptide stability, influence conformation, or provide fluorescent properties, making it valuable for designing peptides with specific functionalities for research or therapeutic applications.
  2. Organic Synthesis: Beyond peptides, this molecule can act as a chiral synthon in the construction of complex organic molecules. Its reactive functional groups and chiral center offer opportunities for asymmetric synthesis.
  3. Medicinal Chemistry: Researchers utilize such compounds to explore structure-activity relationships (SAR) and to develop novel drug candidates with improved pharmacological properties.

NINGBO INNO PHARMCHEM CO.,LTD. is committed to ensuring that scientists have access to these vital chemical tools. By providing high-quality N-Fmoc-3-(1-naphthyl)-D-alanine, we aim to facilitate breakthroughs in peptide science, drug discovery, and organic synthesis.