Navigating the landscape of chemical synthesis requires a thorough understanding of the properties of the reagents and intermediates employed. 1,4-Dibromo-2-fluorobenzene (CAS 1435-52-5) is a prime example of a compound whose specific characteristics dictate its utility and handling. This article aims to provide a comprehensive overview of its key physical and chemical properties, offering valuable insights for researchers and industrial chemists alike.

Physically, 1,4-dibromo-2-fluorobenzene presents as a white crystalline solid. Its melting point typically ranges between 33-36 °C, indicating it transitions from solid to liquid at a relatively low temperature. This property is important for dissolution and reaction setup. The boiling point is recorded at 216 °C, suggesting good thermal stability for many synthetic procedures. Its density is approximately 2.0491, a factor relevant in volumetric calculations. The compound is noted for its insolubility in water but good solubility in common organic solvents, a characteristic that is fundamental for its use in reactions conducted in non-aqueous media.

Chemically, the molecule's significance lies in its functional groups. The presence of two bromine atoms on the benzene ring makes it highly amenable to palladium-catalyzed cross-coupling reactions. These reactions, integral to the formation of new carbon-carbon bonds, are central to many organic synthesis building blocks strategies. The fluorine atom, being highly electronegative, influences the electron distribution within the aromatic ring, potentially affecting the reactivity of the bromine atoms and the overall electronic properties of derived molecules. This makes it a crucial component when considering fluorinated aromatic compounds uses in advanced materials or pharmaceuticals.

The purity of 1,4-dibromo-2-fluorobenzene is a critical factor for reliable synthetic outcomes. Manufacturers often specify purity levels of 97% or higher. Ensuring the quality of this chemical intermediate is essential for reproducible experimental results and avoiding unwanted side reactions. When sourcing this compound, understanding the CAS 1435-52-5 applications is key to selecting the appropriate grade and ensuring it meets the specific demands of the intended reaction, whether it's for preparing advanced pharmaceutical intermediates or novel electronic materials.

For professionals in need of this compound, NINGBO INNO PHARMCHEM CO.,LTD. provides a reliable source for high-purity 1,4-dibromo-2-fluorobenzene. Their commitment to quality ensures that researchers can confidently incorporate this versatile chemical into their synthetic pathways, trusting in the consistency of its properties and performance. Understanding these properties is the first step towards unlocking the full potential of this essential chemical building block.