4-Fluorobenzoyl Chloride, identified by its CAS number 403-43-0, is a chemical compound of significant interest due to its unique properties and reactivity. As a key intermediate, understanding its chemical characteristics and how it is synthesized is crucial for its effective application in various industries. NINGBO INNO PHARMCHEM CO.,LTD., a leading chemical manufacturer, provides valuable insights into this compound's nature.

Chemically, 4-Fluorobenzoyl Chloride is an acyl chloride derivative of 4-fluorobenzoic acid. Its molecular formula is C7H4ClFO, and it possesses a molecular weight of 158.56. The compound is typically described as a colorless transparent liquid. Its reactive nature, particularly the presence of the acyl chloride group, makes it an excellent acylating agent. This reactivity is fundamental to its role as an intermediate in numerous organic synthesis pathways. The fluorine atom also influences its electronic properties, contributing to its specific behavior in chemical reactions.

While specific proprietary synthesis routes vary, the general production of 4-Fluorobenzoyl Chloride often involves the conversion of 4-fluorobenzoic acid. Common methods for converting carboxylic acids into acyl chlorides include treatment with reagents such as thionyl chloride (SOCl2) or phosphorus pentachloride (PCl5). These reactions replace the hydroxyl group of the carboxylic acid with a chlorine atom, yielding the highly reactive acyl chloride. Ensuring high purity, often u226599% as typically specified, requires careful control of reaction conditions, purification steps, and quality assurance protocols, areas where NINGBO INNO PHARMCHEM CO.,LTD. excels.

The typical properties of 4-Fluorobenzoyl Chloride, as highlighted by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., include its assay (u226599%), and limitations on impurities such as 4-Fluorobenzotrichloride (u22640.2%), 4-Fluorobenzoic acid (u22640.15%), and various positional isomers of fluorobenzoyl chloride. Proper storage is also emphasized, recommending a cool, dry, and well-ventilated place away from fire, heat, light, acids, and incompatible food materials to maintain its stability and efficacy.