For chemists engaged in organic synthesis, a thorough understanding of a compound's properties is fundamental to successful experimentation and product development. 1-Bromo-3-fluoro-2-nitrobenzene (CAS 886762-70-5) is a prime example of a chemical intermediate whose utility is deeply rooted in its distinct physical and chemical characteristics. From its appearance and melting point to its reactivity profile, these attributes guide its application in creating complex molecules. NINGBO INNO PHARMCHEM CO.,LTD. provides this vital intermediate and valuable insights into its properties for the scientific community.

The physical appearance of 1-Bromo-3-fluoro-2-nitrobenzene is typically described as an off-white to light yellow solid. This solid state, coupled with a melting point generally reported between 36-40°C, indicates a compound that is relatively stable under ambient laboratory conditions, facilitating handling and storage. Its molecular formula, C6H3BrFNO2, and a molecular weight of approximately 220 g/mol, are standard data points crucial for stoichiometric calculations in synthesis. The compound's density is around 1.8 g/cm³, and it exhibits a low vapor pressure (0.1±0.4 mmHg at 25°C), suggesting it is not highly volatile, which contributes to safer handling practices and reduces potential losses during reactions.

Chemically, 1-Bromo-3-fluoro-2-nitrobenzene is characterized by the presence of three key functional groups on the benzene ring: a bromine atom, a fluorine atom, and a nitro group. The bromine atom is susceptible to nucleophilic substitution and is an excellent participant in various cross-coupling reactions, such as Suzuki, Stille, and Sonogashira couplings, essential for forming new carbon-carbon bonds. The fluorine atom imparts unique electronic and steric properties, often enhancing the lipophilicity and metabolic stability of molecules it is incorporated into – a highly desirable trait in pharmaceuticals and agrochemicals. The nitro group is electron-withdrawing, influencing the reactivity of the aromatic ring, and can be readily reduced to an amino group, opening doors to a vast array of amine-based chemistry, including heterocycle synthesis. Exploring these diverse 1-Bromo-3-fluoro-2-nitrobenzene applications is a key focus for many researchers.

The flash point of 94.1±21.8°C indicates its flammability, necessitating standard precautions when working with the compound. The refractive index of 1.580 can be relevant in specific spectroscopic analyses or material applications. For chemists and procurement specialists sourcing this compound, understanding these 1-Bromo-3-fluoro-2-nitrobenzene properties is crucial for selecting appropriate reaction conditions, storage methods, and handling procedures to ensure both safety and successful synthetic outcomes. NINGBO INNO PHARMCHEM CO.,LTD. ensures that this intermediate is supplied with the purity (≥98.0%) necessary for demanding synthetic tasks.