3-Fluorobenzyl chloride, known by its CAS number 456-42-8, is a compound that garners significant attention within the organic chemistry community due to its distinct properties and versatile reactivity. The presence of a fluorine atom on the benzene ring, coupled with the reactive chloromethyl group, makes it an excellent candidate for a variety of synthetic transformations. Understanding these characteristics is crucial for chemists planning 3-Fluorobenzyl chloride synthesis projects or incorporating it into larger molecular frameworks.

Physically, 3-Fluorobenzyl chloride typically presents as a liquid with a characteristic pungent odor. Its boiling point is around 176-177 °C, and its density is approximately 1.194 g/mL at 25 °C. The refractive index, n20/D, is around 1.511. These physical parameters are important for accurate handling, storage, and process design. For instance, knowing the density is crucial for mass-to-volume conversions when calculating reaction stoichiometry. The compound's storage temperature is recommended to be below +30°C, and its solubility in water is noted as 40 g/L at 20 °C, indicating moderate water solubility.

The reactivity of 3-Fluorobenzyl chloride stems primarily from the chloromethyl group (-CH2Cl), which is susceptible to nucleophilic substitution reactions. This makes it an effective alkylating agent. The fluorine atom, being electron-withdrawing, can influence the reactivity of the aromatic ring and the benzylic position, though its primary role is often to impart specific electronic or metabolic properties to the final molecule. These characteristics are highly valued when exploring its 3-Fluorobenzyl chloride applications in pharmaceuticals and materials science.

When considering the 3-Fluorobenzyl chloride price, the manufacturing process and purity levels play a significant role. Suppliers like NINGBO INNO PHARMCHEM CO.,LTD. focus on producing high-purity grades, ensuring that the compound performs reliably in sensitive synthetic steps. The compound is also noted as a lachrymator, meaning it can cause irritation to the eyes, highlighting the need for appropriate personal protective equipment and handling procedures. Safety data sheets (SDS) provide comprehensive information on hazard statements (H226, H314, H318) and precautionary measures (P201, P261, P280, etc.).

In essence, 3-Fluorobenzyl chloride is a compound with well-defined physical and chemical properties that make it an invaluable tool for synthetic chemists. Its reactivity, combined with the influence of the fluorine substituent, opens doors to a wide array of chemical transformations. NINGBO INNO PHARMCHEM CO.,LTD. is a leading source for this chemical, offering expertise and reliable supply to support your chemical endeavors. We encourage you to consult our resources for further details on its applications and safe handling.