The field of organic synthesis is constantly evolving, driven by the need for novel molecules with specific functionalities. At the heart of many complex synthesis projects lies the use of specialized chemical intermediates, such as 7-Bromo-2-Methyl-1H-Indene. With its CAS number 880652-93-7, this compound is recognized for its utility as a building block, particularly in the creation of advanced ligands used in catalysis. Understanding its synthesis and inherent properties is key to unlocking its full potential.

The synthesis of 7-Bromo-2-Methyl-1H-Indene typically involves a multi-step reaction sequence. One common route starts with a precursor like 4-bromo-6-chloro-2-methyl-2,3-dihydro-1H-inden-1-one. Through a process that often includes reduction with agents like sodium borohydride, followed by an acid-catalyzed cyclization and subsequent purification, the target compound is obtained. The aim is to achieve a high yield and purity, often resulting in a colorless solid. Researchers frequently look for detailed information on 7-bromo-2-methyl-1h-indene synthesis to replicate or improve upon existing methods.

The chemical properties of 7-Bromo-2-Methyl-1H-Indene are largely defined by its aromatic indene core, the presence of a bromine atom, and a methyl substituent. The bromine atom, in particular, serves as a reactive handle for a wide array of organic transformations. This includes various cross-coupling reactions, such as Suzuki or Stille couplings, which are fundamental in constructing carbon-carbon bonds. The indene structure itself provides a rigid framework, making it ideal for creating ligands that impart specific stereochemical control in catalytic processes. Exploring the various 7-bromo-2-methyl-1h-indene uses reveals its broad applicability.

A significant application of 7-Bromo-2-Methyl-1H-Indene is in the preparation of ansa-zirconocene ligands. These ligands, when coordinated with a zirconium center, form metallocene catalysts that are highly effective in olefin polymerization. The precise structural arrangement provided by the indene framework influences the catalyst's activity, selectivity, and the properties of the resulting polymers. This makes 7-Bromo-2-Methyl-1H-Indene a critical component in the development of next-generation polymerization catalysts. For those in the chemical industry, understanding the price of this intermediate is essential for project budgeting.

When considering the acquisition of 7-Bromo-2-Methyl-1H-Indene, it is crucial to source it from reputable suppliers. NINGBO INNO PHARMCHEM CO.,LTD. is a recognized provider of high-quality fine chemical intermediates, ensuring that researchers and manufacturers receive products that meet stringent purity standards. Whether you are looking to buy small quantities for research or larger volumes for production, NINGBO INNO PHARMCHEM CO.,LTD. is equipped to meet your needs. Proper handling, guided by the SDS and general laboratory safety practices, is also essential.

In summary, 7-Bromo-2-Methyl-1H-Indene is a valuable chemical intermediate whose synthesis and properties are well-documented. Its application in creating ligands for metallocene catalysts highlights its importance in modern chemical science. By partnering with trusted suppliers like NINGBO INNO PHARMCHEM CO.,LTD., you can ensure the quality and availability of this critical compound, facilitating advancements in catalysis and organic synthesis.