At NINGBO INNO PHARMCHEM CO.,LTD., we recognize the indispensable role of high-quality intermediates in advancing scientific discovery. Fmoc-D-1-Naphthylalanine, identified by CAS number 138774-93-3, is one such critical compound. This article aims to shed light on its defining characteristics, particularly its purity, and its wide-ranging applications in chemical synthesis and beyond.

The purity of Fmoc-D-1-Naphthylalanine is a cornerstone of its utility. Typically assessed through High-Performance Liquid Chromatography (HPLC), manufacturers strive for purity levels of 98.0% or higher. Tests often reveal values around 99.66%, a testament to meticulous synthesis and purification processes. This high degree of purity is not merely a number; it directly translates to reliability in complex chemical reactions. In peptide synthesis, for instance, impurities can lead to truncated sequences, altered stereochemistry, or unwanted side products, compromising the integrity of the final peptide. Therefore, employing Fmoc-D-1-Naphthylalanine with verified high purity is essential for achieving reproducible and accurate results.

The chemical structure of Fmoc-D-1-Naphthylalanine, with the molecular formula C28H23NO4 and a molecular weight of 437.49 g/mol, provides a unique building block. The presence of the naphthyl group offers distinct electronic and steric properties compared to standard amino acids like phenylalanine. This uniqueness is leveraged in several areas:

1. Advanced Peptide Design: The naphthyl side chain can introduce hydrophobicity, alter conformational preferences, or serve as a fluorescent tag in synthesized peptides. This is crucial for developing peptides with enhanced biological activity, improved pharmacokinetic profiles, or novel signaling capabilities. Researchers often use Fmoc-D-1-Naphthylalanine for its specific contributions to peptide structure-activity relationships.

2. Pharmaceutical Intermediates: Beyond peptide synthesis, Fmoc-D-1-Naphthylalanine serves as a versatile intermediate in the synthesis of various pharmaceutical compounds. Its chiral nature and reactive functional groups make it a valuable starting material for complex organic molecules with potential therapeutic applications.

3. Research and Development: In academic and industrial research settings, Fmoc-D-1-Naphthylalanine is a staple for exploring new synthetic methodologies, developing novel catalysts, or investigating structure-property relationships in organic materials.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying researchers with the high-quality intermediates they need. Our commitment to purity and consistency in compounds like Fmoc-D-1-Naphthylalanine ensures that your research and development efforts are built on a foundation of reliable chemical components. We understand that sourcing the right materials is critical for success in the competitive landscape of chemical synthesis and drug discovery.