The Role of Fmoc-D-2-Iodophenylalanine in Modern Peptide Synthesis
NINGBO INNO PHARMCHEM CO.,LTD. is proud to highlight the significance of specialized chemical compounds in advancing scientific research. Among these, Fmoc-D-2-Iodophenylalanine stands out as a vital building block in the intricate field of peptide synthesis. This amino acid derivative, often referred to by its CAS number 478183-65-2, offers unique advantages for researchers seeking to create complex and highly pure peptide sequences.
The core of Fmoc-D-2-Iodophenylalanine's utility lies in its dual functionality. Firstly, it incorporates the Fmoc (9-fluorenylmethoxycarbonyl) protecting group. This group is essential for solid-phase peptide synthesis (SPPS), a cornerstone technique for constructing peptides efficiently. The Fmoc group provides a robust yet cleavable protection for the alpha-amino group, allowing for controlled, stepwise addition of amino acids. Its base-lability ensures that it can be removed under mild conditions without affecting other sensitive parts of the growing peptide chain. This characteristic is paramount when aiming for high purity in peptide synthesis.
Secondly, the presence of an iodine atom at the ortho position of the phenyl ring introduces a site for further chemical modification. This halogen atom can participate in various cross-coupling reactions, such as Suzuki or Sonogashira couplings, enabling the introduction of diverse functional groups and creating more complex peptide structures. This capability is particularly valuable in drug development, where precise molecular design is critical for therapeutic efficacy. For instance, exploring novel peptide structures for targeted therapies is a key area where this compound shines.
The application of Fmoc-D-2-Iodophenylalanine extends beyond basic peptide construction. It is instrumental in areas like bioconjugation, where peptides are linked to other molecules to create targeted delivery systems or diagnostic tools. Researchers in cancer therapy research also find this compound invaluable, as its modified peptide structures can be designed to selectively target cancer cells. The ability to precisely engineer these molecules contributes significantly to the search for more effective cancer treatments.
For those looking to purchase this essential chemical, understanding the different suppliers and their offerings is crucial. The availability of Fmoc-D-2-Iodophenylalanine from reliable sources ensures the quality and consistency required for demanding research projects. When considering the buy process for such specialized reagents, it's important to compare prices and ensure that the supplier meets stringent quality standards. The price of Fmoc-D-2-Iodophenylalanine can vary based on purity and quantity, making it important for researchers to conduct thorough research.
In summary, Fmoc-D-2-Iodophenylalanine is more than just an amino acid derivative; it is a sophisticated tool that empowers advancements in peptide synthesis and opens new avenues for drug discovery. Its unique combination of Fmoc protection and iodination makes it indispensable for creating the next generation of therapeutic peptides and small molecules.
Perspectives & Insights
Molecule Vision 7
“Secondly, the presence of an iodine atom at the ortho position of the phenyl ring introduces a site for further chemical modification.”
Alpha Origin 24
“This halogen atom can participate in various cross-coupling reactions, such as Suzuki or Sonogashira couplings, enabling the introduction of diverse functional groups and creating more complex peptide structures.”
Future Analyst X
“This capability is particularly valuable in drug development, where precise molecular design is critical for therapeutic efficacy.”