The Chemical Profile of 2-Chloro-5-Chloromethylthiazole: Properties and Specifications
Understanding the precise chemical and physical properties of an intermediate is paramount for its successful application in industrial processes. 2-Chloro-5-Chloromethylthiazole (CCMT) is no exception. This compound, critical for both agrochemical and pharmaceutical synthesis, possesses a specific profile that dictates its handling, storage, and use.
The most commonly cited appearance for CCMT is a liquid, often described as colorless or light yellow. This physical state is dependent on temperature, as it can exist as a white or light yellow solid at lower temperatures, with a melting point typically ranging between 29-31°C. Its molecular formula is C4H3Cl2NS, and it has a molecular weight of approximately 168.04 g/mol. These fundamental properties are critical for chemists and engineers when designing reaction conditions and ensuring proper material handling.
In terms of purity, CCMT is generally available with a minimum content of 98.5%. Higher purity grades, such as 99% (GCMS), are also common, especially for demanding pharmaceutical applications. The presence of impurities like isothiocyanate is typically kept low, with a maximum of 0.5%. Water content is also precisely controlled, usually between 0.05-0.1%. These specifications are crucial for ensuring the efficiency and reproducibility of synthetic pathways, whether producing insecticides or medications. Reliable CCMT suppliers are those who consistently meet these high purity standards.
The chemical properties of CCMT also include its solubility characteristics. It is generally insoluble in water but soluble in various organic solvents, a common trait for many organic intermediates. Its stability is also a key consideration. While short-term storage at room temperature is often acceptable, longer-term preservation, particularly for maintaining peak purity, typically involves storing it at cooler temperatures, such as 2-8°C or even -20°C, often under an inert atmosphere. Proper handling advice includes protecting it from light and moisture.
For industries relying on CCMT, knowing the exact specifications is vital. Whether it's for the synthesis of thiamethoxam or as a precursor for Ritonavir, the compound's purity, melting point, and stability directly influence reaction yields and the quality of the final product. Companies often request detailed technical data sheets and Certificates of Analysis (COA) when they purchase CCMT to verify these specifications. Understanding these chemical profiles allows for informed decisions regarding sourcing, storage, and application, ensuring the successful integration of CCMT into complex chemical manufacturing processes.
Perspectives & Insights
Agile Reader One
“These fundamental properties are critical for chemists and engineers when designing reaction conditions and ensuring proper material handling.”
Logic Vision Labs
“Higher purity grades, such as 99% (GCMS), are also common, especially for demanding pharmaceutical applications.”
Molecule Origin 88
“The presence of impurities like isothiocyanate is typically kept low, with a maximum of 0.”