3-Picoline N-Oxide, also identified as 3-Methylpyridine N-Oxide (CAS: 1003-73-2), is an organic chemical compound that holds significant importance as an intermediate in several industrial applications, most notably in the agrochemical and pharmaceutical sectors.

Chemically, 3-Picoline N-Oxide is a derivative of pyridine, characterized by a methyl group at the 3-position and an N-oxide functional group. It typically presents as a slight yellow crystalline powder and is known to be soluble in water. Its melting point is reported to be in the range of 37-39 °C, indicating a low-melting solid nature. The compound's stability and reactivity are key factors in its utility, and it is often supplied with a high purity assay of 99.0% or more, ensuring its suitability for sensitive chemical processes.

The synthesis of 3-Picoline N-Oxide typically involves the oxidation of 3-picoline. Hydrogen peroxide is commonly used as the oxidizing agent in this process, often in the presence of a suitable catalyst or under specific reaction conditions to achieve efficient conversion. The purification of the N-oxide product is critical to meet the stringent quality standards required by its end-use applications. Various methods can be employed for purification, ensuring that the final product is free from impurities that could hinder subsequent reactions or compromise the quality of the downstream products.

The primary industrial application of 3-Picoline N-Oxide lies in its role as an intermediate for synthesizing agrochemicals. It is a crucial precursor in the manufacturing process of important insecticides like acetamiprid and imidacloprid. These pesticides are vital for modern agricultural practices, helping farmers protect crops from pests and diseases, thereby ensuring higher yields and better quality produce. The chemical pathway leading to these insecticides often involves the conversion of 3-Picoline N-Oxide to other intermediates, such as 2-chloro-5-methylpyridine, which then proceeds through further reactions.

In addition to its agrochemical applications, 3-Picoline N-Oxide also finds use in the preparation of nicotine derivatives, which can have applications in pharmaceuticals and research. Its versatility as a chemical intermediate makes it a valuable compound for chemists engaged in organic synthesis, offering a platform for creating a diverse range of molecular structures.

For businesses looking to purchase 3-Picoline N-Oxide, identifying reliable suppliers is paramount. Factors such as product purity, packaging options (often 25kg drums or custom designs), and storage recommendations (cool, dry, well-ventilated places) are important considerations to ensure product integrity and safe handling.