The precise control over drug release is a critical objective in pharmaceutical formulation, and Hydroxypropyl Methyl Cellulose Acetate Succinate (HPMCAS) offers a sophisticated solution for achieving tailored release profiles. NINGBO INNO PHARMCHEM CO.,LTD. supplies HPMCAS, a versatile pharmaceutical excipient whose unique properties are key to unlocking advanced drug delivery capabilities.

HPMCAS is characterized by its pH-dependent solubility, a feature that is fundamental to its function in enteric coatings and controlled-release systems. Unlike many other coating materials, HPMCAS maintains its integrity in the acidic environment of the stomach. Upon encountering the higher pH conditions of the small intestine, it rapidly dissolves, facilitating the release of the encapsulated drug. The specific pH at which dissolution occurs can be fine-tuned by varying the acetyl and succinoyl substitution levels on the HPMCAS polymer chain, offering formulators a remarkable degree of control over the drug release site and timing.

This pH-tunability is what makes HPMCAS particularly valuable for sustained-release formulations. By selecting specific grades of HPMCAS (identified by variants of CAS 71138-97-1), formulators can design drug products that release their therapeutic agents over a predetermined period. This ensures a steady drug concentration in the body, minimizing fluctuations and potentially reducing side effects associated with peak-and-trough drug levels. NINGBO INNO PHARMCHEM CO.,LTD. provides a range of HPMCAS grades to meet diverse release profile requirements.

Moreover, HPMCAS is also recognized for its excellent film-forming capabilities, which are essential for creating robust and uniform coatings. These films not only provide the necessary barrier protection but also contribute to the mechanical integrity of the dosage form. When used in combination with other excipients, HPMCAS can be part of complex matrix systems or diffusion-controlled coatings, further expanding the possibilities for precise drug delivery.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supplying high-purity HPMCAS that supports these sophisticated applications. Whether you are developing enteric-coated tablets, controlled-release pellets, or advanced amorphous solid dispersions, our HPMCAS is engineered to deliver consistent performance. For those seeking to optimize drug release and improve patient outcomes, understanding and utilizing the specific properties of HPMCAS is key. Contact us to learn more about how our HPMCAS can elevate your formulation strategies and to purchase HPMCAS for your pharmaceutical needs.