In the intricate world of chemical synthesis, understanding the nuances of key intermediates is crucial for innovation and production efficiency. 3-(4-Nitrophenyl)Pyridine (CAS: 4282-46-6) stands out as a significant compound, primarily recognized for its role in the synthesis of the anticancer drug Niraparib. This article, from the perspective of NINGBO INNO PHARMCHEM CO.,LTD., aims to provide a comprehensive overview of this vital chemical, covering its properties, synthesis considerations, and market relevance, with a particular focus on manufacturing excellence in China.

Unpacking the Chemical Identity: Properties and Structure

3-(4-Nitrophenyl)Pyridine, with the molecular formula C11H8N2O2 and a molecular weight of 200.19300, is characterized by its specific arrangement of a nitrophenyl group attached to a pyridine ring. Its physical and chemical attributes are key to its industrial utility. The compound exhibits a density of 1.252 g/cm³, indicating a relatively dense substance. With a high boiling point of 364.6ºC at 760 mmHg, it demonstrates good thermal stability, making it suitable for reactions requiring elevated temperatures. The flash point of 174.3ºC also contributes to its safety profile during handling and storage.

A critical factor for its application, especially in the pharmaceutical industry, is its purity. Typically supplied at ≥98.0% assay, 3-(4-Nitrophenyl)Pyridine meets the rigorous standards required for advanced chemical synthesis, ensuring reliability and consistency in downstream processes. This emphasis on purity is a hallmark of leading high purity chemical suppliers China.

The Pivotal Role in Niraparib Synthesis

The primary driver for the market presence of 3-(4-Nitrophenyl)Pyridine is its essential function as a precursor in the synthesis of Niraparib. Niraparib is a PARP inhibitor that has revolutionized the treatment of certain cancers, notably ovarian cancer. The complex multi-step synthesis of Niraparib relies on specific intermediates to build its active molecular structure. 3-(4-Nitrophenyl)Pyridine serves as a critical starting point or intermediate in these pathways, directly contributing to the availability of this life-saving medication. The demand for efficient and reliable Niraparib intermediate synthesis processes keeps 3-(4-Nitrophenyl)Pyridine in high regard.

Manufacturing Excellence in China

China's prowess in chemical manufacturing offers significant advantages for the global supply of intermediates like 3-(4-Nitrophenyl)Pyridine. Advanced technological capabilities, coupled with robust quality management systems, enable Chinese manufacturers to produce this compound with high purity and consistency. For businesses seeking a dependable 3-(4-Nitrophenyl)Pyridine manufacturer, China offers a competitive and reliable sourcing option. These manufacturers are adept at scaling production to meet market demands, ensuring that the global pharmaceutical and chemical industries have access to this crucial building block.

Beyond Pharmaceuticals: A Versatile Chemical Synthon

While its pharmaceutical applications are significant, the chemical structure of 3-(4-Nitrophenyl)Pyridine also renders it valuable as a general chemical synthesis building block. The presence of the nitro group and the pyridine moiety provides reactive sites that can be exploited in a wide array of organic reactions. This versatility allows it to be used in the research and development of new materials, agrochemicals, and other specialty chemicals, making it a compound with broad potential in various sectors of the chemical industry.

NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing high-quality 3-(4-Nitrophenyl)Pyridine, supporting the critical needs of the pharmaceutical industry and the broader chemical synthesis community. Our commitment to excellence in manufacturing ensures that our partners receive intermediates that meet the highest standards of purity and reliability.