The landscape of pharmaceutical manufacturing is deeply reliant on the consistent availability of high-grade chemical intermediates. 4-Methoxybenzyl Bromide, with CAS number 2746-25-0, is a prime example of such a critical compound. Its primary utility is as an essential intermediate in the synthesis of Tacrolimus, a powerful immunosuppressant that plays a crucial role in organ transplantation and the management of certain inflammatory skin conditions.

Chemically, 4-Methoxybenzyl Bromide is identified as a colorless to light yellow liquid. The compound is valued for its high purity, with a typical assay of ≥98.0%, ensuring its suitability for stringent pharmaceutical processes. Its molecular formula is C8H9BrO, and it possesses a molecular weight of 201.061. Key physical properties, including a boiling point of 241.6±15.0 °C and a flash point of 95.6±21.5 °C, are important considerations for its safe handling, storage, and effective utilization in synthesis. These parameters highlight its role as a reliable building block in chemical reactions.

The paramount importance of 4-Methoxybenzyl Bromide lies in its direct contribution to the synthesis of Tacrolimus. This potent immunosuppressive agent is indispensable for preventing the rejection of transplanted organs, such as kidneys and livers, and is also used topically to treat severe atopic dermatitis. The production of Tacrolimus involves a complex, multi-step synthetic pathway, and 4-Methoxybenzyl Bromide is strategically incorporated at a vital stage to build the core molecular structure. The consistent supply of this high-purity intermediate is critical for pharmaceutical companies aiming to meet the global demand for this essential medication.

For professionals in the chemical and pharmaceutical sectors, understanding the applications and properties of intermediates like 4-Methoxybenzyl Bromide is key to optimizing drug synthesis. Its well-defined chemical reactivity makes it a valuable component for researchers developing new synthetic routes or improving existing ones, contributing to the broader field of Fine Chemical Synthesis Strategies. The availability of such intermediates from reputable suppliers ensures the integrity of the pharmaceutical supply chain.

In conclusion, 4-Methoxybenzyl Bromide (CAS: 2746-25-0) stands as a vital chemical intermediate, underpinning the production of the critical immunosuppressant drug Tacrolimus. Its high purity and specific chemical characteristics make it an indispensable ingredient for advancing pharmaceutical manufacturing and ultimately, improving patient health outcomes.