Amiodarone, identified by CAS number 1951-25-3, is a significant compound within the chemical and pharmaceutical industries, primarily recognized for its potent antiarrhythmic properties. Its complex molecular structure, characterized by the formula C25H29I2NO3 and a molecular weight of 645.31, involves a benzofuran core substituted with iodine atoms and a diethylaminoethoxy group. This unique composition contributes to its lipophilicity and its broad spectrum of pharmacological actions, including blocking multiple ion channels and adrenergic receptors.

For chemical manufacturers and suppliers, understanding the synthesis and properties of Amiodarone is critical. The synthesis typically involves multi-step organic chemistry processes, requiring precise control over reaction conditions to achieve the desired purity and yield. Key intermediates and reagents are essential for its production, making reliable sourcing of high-quality raw materials a priority for companies involved in its manufacture. The typical appearance as a “red powder” is a crucial quality control parameter.

The market relevance of Amiodarone is driven by its established clinical use in treating severe cardiac arrhythmias, such as ventricular tachycardia and atrial fibrillation. Despite its efficacy, the drug is associated with a significant risk of adverse effects, including pulmonary, thyroid, and hepatic toxicity, as well as numerous drug interactions. These factors necessitate stringent quality control measures for Amiodarone, ensuring that batches meet strict specifications for purity and consistency. The long amiodarone half-life also influences its market demand and the required production volumes.

As a pharmaceutical intermediate, Amiodarone plays a crucial role in the supply chain for cardiovascular medications. Its availability and quality directly impact the development and production of life-saving treatments. For chemical companies, focusing on the reliable supply of high-purity Amiodarone and related intermediates is essential. This ensures that the pharmaceutical sector can continue to provide effective treatments while adhering to rigorous safety and quality standards, making it a vital component in the landscape of specialty chemicals and active pharmaceutical ingredients.