Amiodarone, cataloged with CAS number 1951-25-3, is more than just a clinical antiarrhythmic; it serves as a vital compound in scientific research and a key intermediate in pharmaceutical synthesis. Its well-defined chemical structure and complex pharmacological actions make it an invaluable tool for investigating cardiac electrophysiology, ion channel function, and the underlying mechanisms of various cardiovascular diseases. Researchers utilize Amiodarone to explore its effects on multiple ion channels, including potassium, sodium, and calcium channels, providing critical insights into cellular signaling pathways and potential therapeutic targets.

The precise chemical properties of Amiodarone, such as its molecular formula (C25H29I2NO3) and molecular weight (645.31), are essential for its use in synthesis and experimental studies. As a pharmaceutical intermediate, its purity and consistent quality are paramount. Manufacturers rely on standardized production processes to ensure the reliable supply of this compound, facilitating reproducible research outcomes and the development of new drug formulations. The “red powder” appearance is a visual indicator of its physical form, important for quality control checks.

In research settings, Amiodarone is employed to study its impact on thyroid hormone metabolism, its role in phospholipidosis, and its potential cytotoxicity. Its long amiodarone half-life also makes it a subject of interest in studies concerning drug disposition, accumulation, and prolonged exposure effects. The insights gained from these investigations are crucial for understanding not only Amiodarone's clinical behavior but also for designing new drugs with improved safety profiles and targeted actions.

Beyond its direct research applications, Amiodarone's chemical structure serves as a scaffold for the synthesis of related compounds or derivatives. This process of modification and optimization is fundamental to drug discovery and development, aiming to enhance efficacy, reduce toxicity, or alter pharmacokinetic properties. The availability of high-quality Amiodarone as a pharmaceutical intermediate is therefore indispensable for advancing both basic cardiovascular research and the creation of next-generation antiarrhythmic therapies. Its dual role in research and synthesis highlights its continued importance in the pharmaceutical landscape.