The continuous battle against bacterial infections necessitates the ongoing development of novel antimicrobial agents. In this pursuit, chemical intermediates that serve as scaffolds for new drug candidates are invaluable. 1-(4-Hydroxypiperidin-1-yl)ethanone, identified by CAS number 4045-22-1, has emerged as a compound of significant interest due to the promising antibacterial potential observed in its derivatives. This focus on exploring its derivatives highlights a key avenue in pharmaceutical research aimed at addressing the growing challenge of antibiotic resistance.

Research into the antibacterial efficacy of compounds derived from 1-(4-Hydroxypiperidin-1-yl)ethanone typically involves synthesizing a series of related molecules by modifying the core structure. These modifications are carefully designed to enhance interaction with bacterial targets or to improve pharmacokinetic properties. For instance, altering substituents on the piperidine ring or the ethanone portion can lead to compounds with significantly enhanced potency against specific bacterial strains. The initial compound, 1-(4-hydroxypiperidin-1-yl)ethanone itself, serves as a readily accessible starting material for these synthetic efforts. Researchers often source this intermediate from specialized chemical suppliers, ensuring the quality and purity required for effective derivatization. The availability of this compound at a reasonable price further supports extensive research into its derivatives.

Studies have demonstrated that certain derivatives exhibit notable in vitro antibacterial activity, with minimum inhibitory concentrations (MICs) that are comparable to or even better than established antibiotics like ciprofloxacin when tested against various pathogens such as E. coli and S. aureus. This preclinical evidence is crucial for validating the potential of this chemical class as a source of new antibacterial drugs. The ability to purchase 1-(4-hydroxypiperidin-1-yl)ethanone allows researchers to conduct these critical structure-activity relationship studies systematically. Understanding the optimal sourcing and pricing for such intermediates is vital for maintaining research momentum.

The exploration of 1-(4-Hydroxypiperidin-1-yl)ethanone derivatives in antibacterial research is a testament to the ongoing innovation in medicinal chemistry. By leveraging the inherent chemical versatility of this intermediate, scientists are working towards identifying lead compounds that could form the basis of next-generation antibiotics. The journey from a promising intermediate to a clinically viable drug is long and complex, involving rigorous testing and optimization. However, the initial findings regarding the antibacterial activity of compounds synthesized from CAS 4045-22-1 offer a hopeful outlook.

In conclusion, 1-(4-Hydroxypiperidin-1-yl)ethanone (CAS 4045-22-1) is more than just a chemical intermediate; it represents a crucial starting point for the development of potentially life-saving antibacterial agents. The ongoing research into its derivatives underscores its importance in pharmaceutical R&D, offering a promising direction in the fight against microbial resistance. As the scientific community continues to investigate its potential, the compound's role in advancing healthcare is likely to grow.