At NINGBO INNO PHARMCHEM CO.,LTD., our expertise lies in the meticulous production of high-quality pharmaceutical intermediates, and Barnidipine (CAS 104713-75-9) is a prime example of our commitment to chemical excellence. As a cornerstone in the development of antihypertensive medications, understanding its specific chemical properties and the manufacturing processes involved is crucial for our clients in the pharmaceutical sector.

Barnidipine is a potent dihydropyridine calcium channel blocker, recognized for its long-acting profile and effectiveness in managing hypertension. Its molecular structure, C27H29N3O6, features a characteristic dihydropyridine ring and a nitro-substituted phenyl group, alongside a chiral pyrrolidinyl methyl ester moiety. The presence of two chiral centers means Barnidipine can exist as four stereoisomers, but its therapeutic activity is primarily attributed to the specific (3'S,4S) enantiomer. This enantiomeric purity is a key focus in our Barnidipine synthesis process.

The physical and chemical properties of Barnidipine are critical for its formulation and efficacy. It typically presents as a white to off-white crystalline powder. Key parameters like its melting point, usually around 137-139°C, and specific optical rotation (αD20 +64.8° in methanol) serve as vital quality control checkpoints. Solubility in polar solvents like DMSO and methanol is also an important consideration for processing. At NINGBO INNO PHARMCHEM CO.,LTD., we rigorously test these properties to ensure batch-to-batch consistency.

The manufacturing of Barnidipine involves intricate organic synthesis, often starting from readily available precursors like 3-nitrobenzaldehyde and specific pyrrolidine derivatives. The controlled assembly of these components, followed by stereoselective steps, culminates in the formation of the desired (3'S,4S) enantiomer. Ensuring the efficiency and scalability of the Barnidipine synthesis process is an ongoing effort in chemical engineering, aimed at providing a reliable supply to the pharmaceutical intermediates market.

For pharmaceutical companies seeking to procure this essential intermediate, the ability to buy Barnidipine online from reputable Barnidipine suppliers China like NINGBO INNO PHARMCHEM CO.,LTD. is invaluable. We provide detailed specifications and Certificates of Analysis, ensuring full transparency regarding the compound's chemical properties and purity, which is crucial for its use as a calcium channel blocker antihypertensive.

Our dedication to manufacturing excellence ensures that the Barnidipine we supply meets the highest industry standards. By focusing on precise chemical synthesis and thorough quality control, NINGBO INNO PHARMCHEM CO.,LTD. contributes to the reliable production of vital cardiovascular medications. We understand the nuances of working with chiral pharmaceutical compounds and are committed to supporting our clients' needs.

In conclusion, Barnidipine (CAS 104713-75-9) is a complex and important pharmaceutical intermediate. NINGBO INNO PHARMCHEM CO.,LTD.'s expertise in its chemical properties and manufacturing excellence ensures a dependable source for the global pharmaceutical industry, supporting the development and availability of critical antihypertensive treatments.