The Biochemistry of Beta Nicotinamide Mononucleotide (NMN): Synthesis and Properties
Understanding the fundamental biochemistry of compounds is key to unlocking their full potential. Beta Nicotinamide Mononucleotide (NMN) is a molecule of significant scientific interest, primarily due to its role as a precursor to Nicotinamide Adenine Dinucleotide (NAD+). NINGBO INNO PHARMCHEM CO.,LTD. provides high-quality NMN and information to illuminate its biochemical landscape.
NMN is a nucleotide derived from ribose and nicotinamide. Its existence is critical for the biosynthesis of NAD+, a coenzyme essential for cellular energy metabolism, DNA repair, and numerous other cellular functions. In vivo, NMN is synthesized through various pathways, notably the salvage pathway involving the enzyme Nicotinamide Phosphoribosyltransferase (NAMPT). This enzyme catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate (PRPP) to produce NMN.
Once synthesized, NMN is further converted into NAD+ by the enzyme NMN Adenylyltransferase (NMNAT). This pathway is central to maintaining adequate intracellular NAD+ levels, which are known to decline with age. The efficiency and regulation of these biosynthetic steps are crucial for cellular health and overall metabolic function.
Key biochemical properties of NMN include its solubility in water and its crystalline powder form, typically white in appearance. Its molecular formula is C11H15N2O8P, with a molecular weight of approximately 334.22 g/mol. These physical and chemical characteristics are important for its handling, formulation, and application in research settings. The purity of NMN is also a critical factor, with high-purity (>95% or >98%) material being essential for reliable experimental results.
NINGBO INNO PHARMCHEM CO.,LTD. focuses on producing and supplying NMN that meets stringent quality standards. By understanding the precise biochemical pathways and properties of NMN, researchers can better utilize this compound in studies related to energy metabolism, aging, and various disease models. Our commitment is to provide the scientific community with the reliable building blocks needed for groundbreaking research.
Perspectives & Insights
Data Seeker X
“Once synthesized, NMN is further converted into NAD+ by the enzyme NMN Adenylyltransferase (NMNAT).”
Chem Reader AI
“This pathway is central to maintaining adequate intracellular NAD+ levels, which are known to decline with age.”
Agile Vision 2025
“The efficiency and regulation of these biosynthetic steps are crucial for cellular health and overall metabolic function.”