Understanding the precise chemical identity and reactivity of intermediates is fundamental to successful chemical synthesis. NINGBO INNO PHARMCHEM CO.,LTD. highlights 4-Amino-3,5-dichlorophenacyl bromide (CAS: 37148-47-3) as a compound of significant interest due to its chemical structure and broad applicability in synthesis. This article provides an overview of its identity and its synthesis applications, particularly within the pharmaceutical landscape.

4-Amino-3,5-dichlorophenacyl bromide, also known by its IUPAC name 1-(4-amino-3,5-dichlorophenyl)-2-bromoethanone, is chemically defined by its formula C8H6BrCl2NO and a molecular weight of approximately 282.95 g/mol. Its appearance is typically described as a yellow solid, with a melting point recorded around 145ºC. The molecule features a benzene ring substituted with an amino group and two chlorine atoms, attached to an alpha-bromo ketone moiety. This particular arrangement of functional groups dictates its chemical behavior and its utility as a synthetic intermediate.

The synthesis applications of 4-Amino-3,5-dichlorophenacyl bromide are diverse and impactful. In the pharmaceutical industry, it serves as a precursor for a range of active pharmaceutical ingredients (APIs). For instance, its reactive alpha-bromine atom readily undergoes nucleophilic displacement reactions, allowing for the attachment of various nucleophiles to build more complex molecular architectures. The amino group on the phenyl ring can also be modified through acylation or alkylation, further expanding the synthetic possibilities. This makes it an invaluable tool for researchers involved in drug discovery and medicinal chemistry.

The compound's role as a pharmaceutical intermediate is well-documented. It is often used in the synthesis of molecules that exhibit specific biological activities, such as certain types of adrenergic agonists or compounds investigated for their therapeutic potential. The precise introduction of the bromoacetyl group and the substituted aniline moiety makes it ideal for cyclization reactions or for building specific pharmacophores required for drug efficacy. NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of sourcing this intermediate from reputable suppliers to ensure the required purity and consistency for GMP-compliant synthesis.

Beyond pharmaceuticals, 4-Amino-3,5-dichlorophenacyl bromide finds applications in the synthesis of other fine chemicals and materials. Its reactivity allows it to be incorporated into polymers or used as a starting material for creating novel organic compounds with unique properties. Researchers exploring new synthetic methodologies or developing custom chemicals often turn to this compound due to its well-defined structure and predictable reactivity. The availability of comprehensive technical data, including CAS registration, aids in its seamless integration into laboratory workflows.

In conclusion, the chemical identity of 4-Amino-3,5-dichlorophenacyl bromide, characterized by its formula, CAS number, and functional groups, underpins its significant utility in synthesis. Its applications as a pharmaceutical intermediate and a versatile reagent in organic chemistry highlight its importance in advancing scientific discovery and chemical manufacturing. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing this critical intermediate to support innovation across the chemical sciences.