Ethyl 2-oxo-4-phenylbutyrate (CAS 64920-29-2) is a chemical compound that plays a pivotal role in the pharmaceutical industry. Known scientifically as Ethyl 2-oxo-4-phenylbutanoate, this substance is characterized by its light yellow oily liquid appearance. Its molecular formula, C12H14O3, and a molecular weight of approximately 206.24 g/mol, define its fundamental chemical identity. A thorough understanding of its physical and chemical properties is crucial for its effective utilization as a pharmaceutical intermediate in the synthesis of drugs like Lisinopril and Cilastatin.

Key physical properties of Ethyl 2-oxo-4-phenylbutyrate include a reported boiling point of around 132°C at 2 mmHg, and a density of approximately 1.091 g/mL at 25°C. These parameters provide critical information for process engineers and chemists when designing reaction conditions and handling procedures. The compound's refractive index is also noted, typically around 1.504, which can be useful in quality control assessments. Its solubility characteristics, such as being slightly soluble in chloroform and ethyl acetate, are also important considerations for extraction and purification processes during synthesis.

Chemically, Ethyl 2-oxo-4-phenylbutyrate is an aliphatic α-ketoester. This structural feature makes it a valuable building block in organic synthesis. Its ability to participate in various chemical reactions makes it a versatile intermediate for creating more complex molecules. The compound's stability and predictable behavior under typical laboratory and industrial conditions are significant advantages. Manufacturers often provide detailed specifications, including assay purity, which is commonly stated as ≥95.0%, ensuring that the material meets the high standards required for pharmaceutical applications.

The applications of Ethyl 2-oxo-4-phenylbutyrate are primarily centered around its role in drug development. As an intermediate, it is essential for the production of Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and heart failure. It is also a precursor for Cilastatin, which is used in combination with certain antibiotics to prevent their breakdown, thereby enhancing their therapeutic effect. These applications underscore the compound's importance in addressing significant public health challenges.

For businesses in the pharmaceutical sector, sourcing high-quality Ethyl 2-oxo-4-phenylbutyrate from reliable suppliers, such as those in China, is a strategic imperative. Companies like NINGBO INNO PHARMCHEM CO.,LTD. specialize in providing such intermediates, often with extensive quality control measures in place. Understanding the detailed chemical profile of this compound allows for informed procurement decisions and successful integration into complex manufacturing processes, ultimately contributing to the development of life-saving medicines.