Understanding the intricate chemical properties of key intermediates is fundamental to advancements in pharmaceutical synthesis. 6-Fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene, identified by CAS number 99199-90-3, is one such compound, playing a crucial role as a precursor in the development of important pharmaceuticals like Nebivolol hydrochloride. This article delves into the chemical characteristics and applications of this vital intermediate, highlighting why it is sought after by researchers and manufacturers globally. For those seeking to buy 6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene, a detailed understanding of its nature is essential.

The compound boasts a molecular formula of C11H11FO2, with a molecular weight of 194.202. Its structure features a 3,4-dihydro-2H-chromene core with a fluorine substituent at the 6-position and an oxirane (epoxide) ring attached at the 2-position. This oxirane ring is a highly reactive functional group, critical for the subsequent steps in the synthesis of complex molecules like Nebivolol. The presence of fluorine also influences the compound's electronic properties and metabolic stability, which are important considerations in drug design. The synthesis of 6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene itself involves precise chemical reactions, ensuring the desired stereochemistry and purity are achieved.

Physically, it is described as a yellow liquid with a density of 1.299 g/cm³ and a boiling point of 292°C. These properties indicate a relatively stable yet reactive compound that can be handled and processed under controlled industrial conditions. The meticulous quality control by manufacturers, such as NINGBO INNO PHARMCHEM CO.,LTD., ensures that the material meets the high purity standards required for pharmaceutical applications (≥95%). This dedication is what makes them a leading nebulic acid intermediate supplier.

The primary application of 6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene lies in its role as a key intermediate for Nebivolol hydrochloride. Nebivolol is a highly selective beta-1 adrenergic receptor antagonist with vasodilating properties, used to treat hypertension. The accurate incorporation of this intermediate into the synthesis pathway is critical for the formation of the active pharmaceutical ingredient (API). Companies looking for a reliable 6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene manufacturer often prioritize those with strong R&D capabilities and a commitment to consistent quality.

In essence, 6-fluoro-2-(oxiran-2-yl)-3,4-dihydro-2H-chromene represents more than just a chemical; it is a vital link in the chain of pharmaceutical innovation. Its specific chemical properties and well-defined applications, particularly as a critical API intermediate, underscore its importance in modern medicine. Manufacturers and researchers alike rely on the expertise of companies like NINGBO INNO PHARMCHEM CO.,LTD. to access this essential building block for advancing healthcare.